CAJ | 학술논문

脂肪细胞因子是指从脂肪组织分离的生物活性分子,包括细胞因子、生长因子、炎性蛋白等,与肥胖、胰岛素抵抗等密切相关.胰岛素与靶细胞膜上特异受体结合后发挥正常的信号转导作用,而该转导途径直接或者间接地受大部分脂肪细胞因子的负件调节,导致机体出现胰岛素抵抗及其相父疾病.本文综述了胰岛素信号转导作用、代谢综合征患者血浆脂肪细胞因子水平的变化以及脂肪细胞因子调节胰岛素信号转导的机制.
지방세포인자시지종지방조직분리적생물활성분자,포괄세포인자、생장인자、염성단백등,여비반、이도소저항등밀절상관.이도소여파세포막상특이수체결합후발휘정상적신호전도작용,이해전도도경직접혹자간접지수대부분지방세포인자적부건조절,도치궤체출현이도소저항급기상부질병.본문종술료이도소신호전도작용、대사종합정환자혈장지방세포인자수평적변화이급지방세포인자조절이도소신호전도적궤제.
Adipokines,including cytokines, growth factors,inflammation proteins and so on, are bio-active molecules originated from adipose tissue, and are tightly related to obesity and insulin resistance. Insu-lin combines with the special receptor on the membrane of target cells and initiates normal signal transduc-tion. However,the signal transduction pathways are negatively regulated directly or indirectly by most of the adipokines,which results in insulin resistance and correlated disorders. This article reviews the insulin signal transduction action, investigations of plasma adipokine level in patients with metabolic syndrome, and the mechanism of adipokines regulating the insulin signal transduction.