中华放射医学与防护杂志
中華放射醫學與防護雜誌
중화방사의학여방호잡지
Chinese Journal of Radiological Medicine and Protection
2011年
3期
294-298
,共5页
目的 研究S波段微波长期间歇照射对大鼠内分泌功能的影响.方法 二级Wistar 大鼠雌雄各半,随机分为假照射(对照)和照射组,分别给予4、10和20 mW/cm2照射,每次照射6min,每周固定2次照射,共照射12周.分别在照射的4、8和12周和停止照射后4周分批活杀,分离血清进行12项内分泌指标检测.结果 S波段微波长期间歇照射后,大鼠血清内分泌有部分指标出现变化.其中雌性大鼠随着照射时间延长,T3水平先降低后上升,10 mW/cm2组在照射8和12周、4及20 mW/cm2组在照射12周均明显升高(t=-2.586、-2.642、-5.075、-4.365,P＜0.05).FT3变化趋势与T3类似,照射4周时4及10 mW/cm2组雌性大鼠FT3水平明显低于对照组(t=2.275、2.510,P＜0.05),随后升高;照射12周3个照射组均明显高于对照组(t=-2.636,-2.851、-5.240,P＜0.05).TSH在照射4周时降低,其中10 mW/cm2组与对照组相比降低显著(t=2.300,P＜0.05),然后升高;20 mW/cm2组在照射8和12周时与对照组相比增高显著(t=-2.838、-3.651,P＜0.05).雄性大鼠皮质醇(COR)及促肾上腺皮质激素(ACTH)呈波动性变化,其中COR的4、10和20 mW/cm2组在照射8周时与对照组相比增高显著(t=-2.772、-2.234、-2.505,P＜0.05):20 mW/cm2组在照射12周时与对照组相比降低显著(t=3.067,P＜0.05).雌性大鼠E2在照射4周时略低于对照组,随后升高,10 mW/cm2组在照射8周时、3个照射组在照射12周时与对照组相比增高显著(t=-2.322、-3.179、-2.655、-4.716,P＜0.05);停止照射后4周回复,其中4 mW/cm2组E2水平明显低于对照组(t=2.250,P＜0.05).雄性大鼠T水平呈先升后降的趋势,10 mW/cm2组在照射8周时与对照组相比增高显著(t=-2.435,P＜0.05).上述指标在停止照射后均有一定程度恢复.结论 S波段微波长期间歇照射可引起大鼠的内分泌功能性损伤.
目的 研究S波段微波長期間歇照射對大鼠內分泌功能的影響.方法 二級Wistar 大鼠雌雄各半,隨機分為假照射(對照)和照射組,分彆給予4、10和20 mW/cm2照射,每次照射6min,每週固定2次照射,共照射12週.分彆在照射的4、8和12週和停止照射後4週分批活殺,分離血清進行12項內分泌指標檢測.結果 S波段微波長期間歇照射後,大鼠血清內分泌有部分指標齣現變化.其中雌性大鼠隨著照射時間延長,T3水平先降低後上升,10 mW/cm2組在照射8和12週、4及20 mW/cm2組在照射12週均明顯升高(t=-2.586、-2.642、-5.075、-4.365,P＜0.05).FT3變化趨勢與T3類似,照射4週時4及10 mW/cm2組雌性大鼠FT3水平明顯低于對照組(t=2.275、2.510,P＜0.05),隨後升高;照射12週3箇照射組均明顯高于對照組(t=-2.636,-2.851、-5.240,P＜0.05).TSH在照射4週時降低,其中10 mW/cm2組與對照組相比降低顯著(t=2.300,P＜0.05),然後升高;20 mW/cm2組在照射8和12週時與對照組相比增高顯著(t=-2.838、-3.651,P＜0.05).雄性大鼠皮質醇(COR)及促腎上腺皮質激素(ACTH)呈波動性變化,其中COR的4、10和20 mW/cm2組在照射8週時與對照組相比增高顯著(t=-2.772、-2.234、-2.505,P＜0.05):20 mW/cm2組在照射12週時與對照組相比降低顯著(t=3.067,P＜0.05).雌性大鼠E2在照射4週時略低于對照組,隨後升高,10 mW/cm2組在照射8週時、3箇照射組在照射12週時與對照組相比增高顯著(t=-2.322、-3.179、-2.655、-4.716,P＜0.05);停止照射後4週迴複,其中4 mW/cm2組E2水平明顯低于對照組(t=2.250,P＜0.05).雄性大鼠T水平呈先升後降的趨勢,10 mW/cm2組在照射8週時與對照組相比增高顯著(t=-2.435,P＜0.05).上述指標在停止照射後均有一定程度恢複.結論 S波段微波長期間歇照射可引起大鼠的內分泌功能性損傷.
목적 연구S파단미파장기간헐조사대대서내분비공능적영향.방법 이급Wistar 대서자웅각반,수궤분위가조사(대조)화조사조,분별급여4、10화20 mW/cm2조사,매차조사6min,매주고정2차조사,공조사12주.분별재조사적4、8화12주화정지조사후4주분비활살,분리혈청진행12항내분비지표검측.결과 S파단미파장기간헐조사후,대서혈청내분비유부분지표출현변화.기중자성대서수착조사시간연장,T3수평선강저후상승,10 mW/cm2조재조사8화12주、4급20 mW/cm2조재조사12주균명현승고(t=-2.586、-2.642、-5.075、-4.365,P＜0.05).FT3변화추세여T3유사,조사4주시4급10 mW/cm2조자성대서FT3수평명현저우대조조(t=2.275、2.510,P＜0.05),수후승고;조사12주3개조사조균명현고우대조조(t=-2.636,-2.851、-5.240,P＜0.05).TSH재조사4주시강저,기중10 mW/cm2조여대조조상비강저현저(t=2.300,P＜0.05),연후승고;20 mW/cm2조재조사8화12주시여대조조상비증고현저(t=-2.838、-3.651,P＜0.05).웅성대서피질순(COR)급촉신상선피질격소(ACTH)정파동성변화,기중COR적4、10화20 mW/cm2조재조사8주시여대조조상비증고현저(t=-2.772、-2.234、-2.505,P＜0.05):20 mW/cm2조재조사12주시여대조조상비강저현저(t=3.067,P＜0.05).자성대서E2재조사4주시략저우대조조,수후승고,10 mW/cm2조재조사8주시、3개조사조재조사12주시여대조조상비증고현저(t=-2.322、-3.179、-2.655、-4.716,P＜0.05);정지조사후4주회복,기중4 mW/cm2조E2수평명현저우대조조(t=2.250,P＜0.05).웅성대서T수평정선승후강적추세,10 mW/cm2조재조사8주시여대조조상비증고현저(t=-2.435,P＜0.05).상술지표재정지조사후균유일정정도회복.결론 S파단미파장기간헐조사가인기대서적내분비공능성손상.
Objective To observe the effect of S-band micro-wave long-term intermittent irradiation on endocrine function in rats.Methods A total of 192 rats (male and female) were randomly divided into the sham-irradiation (normal control) groups and the irradiation groups.The irradiation groups were exposed with micro-wave at 3 dosages of 4,10 and 20 mW/cm2 for 6 min twice a week for 12 weeks,while no administration was given to control group.The endocrine parameters in blood serum were examined by radioimmunoassay at 4,8,12 week during irradiation and 4 week post-irradiation.Results After the irradiation of S-band microwave,parts of the endocrine parameters changed.T3 in famale rats decreased at first and then increased,especially in 10 mW/cm2 group at 8 and 12 week,20 mW/cm2 group at 4 and 12week(t =-2.586,-2.642,-5.075,-4.365,P <0.05).FT3 in famale rats had the similar trend asT3,significantly lower in 4 and 10 mW/cm2 groups than that in the control group at 4 week (t = 2.275,2.510,P <0.05),then increased,especially in three irradiation groups at 12 week (t =-2.636,-2.851,-5.240,P < 0.05).TSH decreased at 4 week,especially in 10 mW/cm2 group (t = 2.300,P < 0.05) ; and then increased in the irradiation groups at 20 mW/cm2 at 8 and 12 week (t =-2.838,-3.651,P <0.05).COR and ACTH in male rats showed changes in volatility,in which the 4,10 and 20 mW/cm2 groups at 8 week increased significantly (t =-2.772,-2.234,-2.505,P < 0.05),while 20 mW/cm2 group at 12 week decreased significantly (t=3.067,P < 0.05).E2 in female rats was slightly lower in irradiation groups at 4 week than the control group,then increased,especially in 10 mW/cm2 group at 8 week,three irradiation groups at 12 week (t =-2.322,-3.179,-2.655,-4.716,P < 0.05),and returned to the normal at 4 week post-irradiation,significantly lower in 4 mW/cm2 group than that in the control group (t = 2.250,P < 0.05).T in male rats increased first and then decreased,especially in 10 mW/cm2 group at 8 week(t =-2.435,P < 0.05).After exposure the above indexes restored to some extent.Conclusions The long-term intermittent irradiation of S-band microwave can cause adverse effects on the endocrine function of rats.
