CAJ | 학술논문

目的研究水飞蓟宾在正常和肝损伤模型大鼠的体内分布与代谢差异.方法分别口饲正常组和免疫性肝损伤模型大鼠相同剂量的水飞蓟宾胶囊水溶液,HPLC法分别测定各类生物样品中不同时间的水飞蓟宾含量.结果正常组在各时间点各类生物样品中的水飞蓟宾含量均比模型组高,且正常组中水飞蓟宾在各脏器中分布的浓度由大到小顺序依次为肝脏＞肾脏＞血浆＞心脏,而模型组中为肾脏＞心脏＞肝脏＞血浆.结论水飞蓟宾在正常大鼠的分布与代谢与肝损伤模型大鼠有显著性差异.
목적 연구수비계빈재정상화간손상모형대서적체내분포여대사차이.방법 분별구사정상조화면역성간손상모형대서상동제량적수비계빈효낭수용액,HPLC법분별측정각류생물양품중불동시간적수비계빈함량.결과 정상조재각시간점각류생물양품중적수비계빈함량균비모형조고,차정상조중수비계빈재각장기중분포적농도유대도소순서의차위간장＞신장＞혈장＞심장,이모형조중위신장＞심장＞간장＞혈장.결론 수비계빈재정상대서적분포여대사여간손상모형대서유현저성차이.
Objective To research the metabolism and distribution ofsilybin in normal rats and liver injury model rats.Methods The normal rats group and immunity liver injury rat models were fed with the same dose ofsilybin capsule,and HPLC was used to determine the silybin concentration in biological samples in different time.Results The silybin concentration in the normal group in biological samples was higher than the model group at different time.In the normal group,the consequence of silybin concentration in each viscera distribution from top to bottom was liver＞kidneys＞plasma＞heart,while in the model group the fact was kidneys＞heart＞liver＞plasma.Conclusion The difference of metabolism and distribution of silybin in normal rats and liver damage model rats was obvious.