中华病理学杂志
中華病理學雜誌
중화병이학잡지
Chinese Journal of Pathology
2010年
4期
249-254
,共6页
马遇庆%苗娜%古丽那尔·阿布拉江%李巧新%刘霞%张巍%王朝夫%王坚
馬遇慶%苗娜%古麗那爾·阿佈拉江%李巧新%劉霞%張巍%王朝伕%王堅
마우경%묘나%고려나이·아포랍강%리교신%류하%장외%왕조부%왕견
胸腺肿瘤%胸腺瘤%免疫组织化学
胸腺腫瘤%胸腺瘤%免疫組織化學
흉선종류%흉선류%면역조직화학
Thymic tumor%Thymoma%Immunohistochemistry
目的 探讨胸腺上皮性肿瘤的临床病理学特点,评价2004年WHO胸腺肿瘤分类的可重复性及其临床意义.方法 收集2001年1月至2009年6月间52例胸腺七皮性肿瘤的资料,对其形态学特征和免疫表型进行回顾性复习,按照2004年WHO胸腺肿瘤分类进行组织学分型,并对临床资料加以分析和总结.结果 胸腺瘤45例,胸腺癌7例.胸腺瘤中以AB型最多见,占33.3%(15/45),其次为B2型和B3型,均为20.0%(9/45).A型和B1型相对少见,分别占13.4%(6/45)和8.9%(4/45).另有2例化生性胸腺瘤(4.4%).7例胸腺癌中6例为鳞状细胞癌分化,1例为神经内分泌癌.临床上,多数患者因咳嗽或胸痛就诊,部分病例为体检中偶然发现.胸腺瘤中13例伴有重症肌无力(25.0%).影像学上,49例(94.2%)位于前纵隔,其中A、AB、B1和多数B2型胸腺瘤表现为边缘光整、密度均匀的肿块,少数B2型、多数B3型胸腺瘤和胸腺癌表现为边界欠清、外形不规则和密度不均的肿块.48例手术Masaoka分期为:Ⅰ期20例(41.7%),Ⅱ期15例(31.3%),Ⅲ期11例(22.9%),Ⅳ期2例(4.1%).分析显示,组织学分型与临床分期有显著相关性(χ~2=32.5,P<0.01).结论 基于细胞形态、功能和遗传学的2004年WHO胸腺肿瘤分类具有较高的可重复性,并在一定程度上反映胸腺瘤各亚型的生物学行为,对临床治疗和预后判断有指导意义.
目的 探討胸腺上皮性腫瘤的臨床病理學特點,評價2004年WHO胸腺腫瘤分類的可重複性及其臨床意義.方法 收集2001年1月至2009年6月間52例胸腺七皮性腫瘤的資料,對其形態學特徵和免疫錶型進行迴顧性複習,按照2004年WHO胸腺腫瘤分類進行組織學分型,併對臨床資料加以分析和總結.結果 胸腺瘤45例,胸腺癌7例.胸腺瘤中以AB型最多見,佔33.3%(15/45),其次為B2型和B3型,均為20.0%(9/45).A型和B1型相對少見,分彆佔13.4%(6/45)和8.9%(4/45).另有2例化生性胸腺瘤(4.4%).7例胸腺癌中6例為鱗狀細胞癌分化,1例為神經內分泌癌.臨床上,多數患者因咳嗽或胸痛就診,部分病例為體檢中偶然髮現.胸腺瘤中13例伴有重癥肌無力(25.0%).影像學上,49例(94.2%)位于前縱隔,其中A、AB、B1和多數B2型胸腺瘤錶現為邊緣光整、密度均勻的腫塊,少數B2型、多數B3型胸腺瘤和胸腺癌錶現為邊界欠清、外形不規則和密度不均的腫塊.48例手術Masaoka分期為:Ⅰ期20例(41.7%),Ⅱ期15例(31.3%),Ⅲ期11例(22.9%),Ⅳ期2例(4.1%).分析顯示,組織學分型與臨床分期有顯著相關性(χ~2=32.5,P<0.01).結論 基于細胞形態、功能和遺傳學的2004年WHO胸腺腫瘤分類具有較高的可重複性,併在一定程度上反映胸腺瘤各亞型的生物學行為,對臨床治療和預後判斷有指導意義.
목적 탐토흉선상피성종류적림상병이학특점,평개2004년WHO흉선종류분류적가중복성급기림상의의.방법 수집2001년1월지2009년6월간52례흉선칠피성종류적자료,대기형태학특정화면역표형진행회고성복습,안조2004년WHO흉선종류분류진행조직학분형,병대림상자료가이분석화총결.결과 흉선류45례,흉선암7례.흉선류중이AB형최다견,점33.3%(15/45),기차위B2형화B3형,균위20.0%(9/45).A형화B1형상대소견,분별점13.4%(6/45)화8.9%(4/45).령유2례화생성흉선류(4.4%).7례흉선암중6례위린상세포암분화,1례위신경내분비암.림상상,다수환자인해수혹흉통취진,부분병례위체검중우연발현.흉선류중13례반유중증기무력(25.0%).영상학상,49례(94.2%)위우전종격,기중A、AB、B1화다수B2형흉선류표현위변연광정、밀도균균적종괴,소수B2형、다수B3형흉선류화흉선암표현위변계흠청、외형불규칙화밀도불균적종괴.48례수술Masaoka분기위:Ⅰ기20례(41.7%),Ⅱ기15례(31.3%),Ⅲ기11례(22.9%),Ⅳ기2례(4.1%).분석현시,조직학분형여림상분기유현저상관성(χ~2=32.5,P<0.01).결론 기우세포형태、공능화유전학적2004년WHO흉선종류분류구유교고적가중복성,병재일정정도상반영흉선류각아형적생물학행위,대림상치료화예후판단유지도의의.
Objective To study the clinicopathologic characteristics of thymic epithelial tumors and to evaluate the diagnostic reproducibility and clinical relevance of the 2004 WHO histolagic classification system.Methods The morphology and immunophenotype of 52 cases of thymic epithelial tumor were reviewed.The tumors were classified according to the new WHO classification system and the clinical data were analyzed.Results Of the 52 cases studied,45 were thymomas and 7 were thymic carcinomas.Amongst the 45 cases of thymoma,6(13.4%)were type A,15(33.3%)were type AB,4(8.9%)were type B1,9(20.0%)were type B2,9(20.0%)were type B3 and 2(4.4%)were metaplastic thymoma.Amongst the 7 cases of thymic carcinoma,6 were squamous cell carcinomas and 1 was neuroendocrine carcinoma.The commonest presentations were cough and chest pain.Some cases were incidentally discovered by routine physical examination.Thirteen cases(25.0%)of thymoma were associated with myasthenia gratis.CT scan showed that 49 cases(94.2%)were located in the anterior mediastinum.All cases of type A,AB and B1 thymoma and most cases of B2 thymoma appeared as well-defined homogeneous mass,whereas a few cases of type B2 thymoma and most cases of type B3 thymoma and thymic carcinoma were poorly demarcated and heterogeneous.According to Masaoka staging system,20 cases(41.7%)belonged to stage Ⅰ,15 cases(31.3%)stage Ⅱ,11 cases(22.9%)stage Ⅲ and2 cases(4.1%)stage Ⅳ.The histologic subtypes of thymic epithelial tumors significantly correlated with the clinical stages(χ~2=32.5,P<0.01).Conclusions The 2004 revision of WHO histoiogic classification system for thymic epithelial tumors shows a high degree of reproducibility.Correlation with the radiologic,clinical and prognostic parameters is helpful in determining the management strategy for individual patients.