中国医药
中國醫藥
중국의약
CHINA MEDICINE
2008年
12期
740-741
,共2页
张会清%余沁楠%刘沛%朱锋
張會清%餘沁楠%劉沛%硃鋒
장회청%여심남%류패%주봉
膀胱癌%核基质蛋白
膀胱癌%覈基質蛋白
방광암%핵기질단백
Bladder neoplasms cancer%Nuclear matrix protein
目的 探讨检测尿核基质蛋白22(NMP22)在膀胱癌筛查中的应用价值.方法 对96例怀疑膀胱癌者进行尿NMP22与尿细胞学检查,比较两者诊断膀胱癌的敏感度和特异度.结果 96例患者中病理证实膀胱移行细胞癌55例,非膀胱癌41例.尿NMP22的敏感度为80.0%、特异度为87.8%;尿细胞学检查的敏感度为41.8%、特异度为97.6%.NMP22在膀胱癌筛查中的敏感度优于尿细胞学检查(P<0.05).结论 尿NMP22检测在膀胱癌筛查中优于尿细胞学检查,可以作为膀胱癌的临床筛查手段.
目的 探討檢測尿覈基質蛋白22(NMP22)在膀胱癌篩查中的應用價值.方法 對96例懷疑膀胱癌者進行尿NMP22與尿細胞學檢查,比較兩者診斷膀胱癌的敏感度和特異度.結果 96例患者中病理證實膀胱移行細胞癌55例,非膀胱癌41例.尿NMP22的敏感度為80.0%、特異度為87.8%;尿細胞學檢查的敏感度為41.8%、特異度為97.6%.NMP22在膀胱癌篩查中的敏感度優于尿細胞學檢查(P<0.05).結論 尿NMP22檢測在膀胱癌篩查中優于尿細胞學檢查,可以作為膀胱癌的臨床篩查手段.
목적 탐토검측뇨핵기질단백22(NMP22)재방광암사사중적응용개치.방법 대96례부의방광암자진행뇨NMP22여뇨세포학검사,비교량자진단방광암적민감도화특이도.결과 96례환자중병리증실방광이행세포암55례,비방광암41례.뇨NMP22적민감도위80.0%、특이도위87.8%;뇨세포학검사적민감도위41.8%、특이도위97.6%.NMP22재방광암사사중적민감도우우뇨세포학검사(P<0.05).결론 뇨NMP22검측재방광암사사중우우뇨세포학검사,가이작위방광암적림상사사수단.
Objective To evaluate the clinical efficacy of nuclear matrix protein(NMP)as a marker for detection of bladder cancer.Methods For 96 patients suspected with bladder cancer NMP and cytology were determined in the same voided urine samples.The sensitivity and specificity of NMP and urine cytology were analyzed.Results Fifty-five patients were pathologically diagnosed as transitional cell carcinoma.and 41 cases were other urological conditions.The sensitivity and specificity of NMP were 80.0%and 87.8%respectively.those of urene cytology were 41.8%and 97.6%respectively.The sensitivity of NMP Was significantly better than urinary cytology in detection of bladder cancer(P<0.05).Conclusion The NMP test iS superior to voided urine cytology in detection of bladder cancer.and it is a effective method for detection of bladder cancer.