中华流行病学杂志
中華流行病學雜誌
중화류행병학잡지
CHINESE JOURNAL OF EPIDEMIOLOGY
2011年
11期
1110-1113
,共4页
刘春灵%田庚善%何耀%周平%王纯巍%王战勇%孙绍权%周艳%孙莹%孙妍%张宏伟%李莉
劉春靈%田庚善%何耀%週平%王純巍%王戰勇%孫紹權%週豔%孫瑩%孫妍%張宏偉%李莉
류춘령%전경선%하요%주평%왕순외%왕전용%손소권%주염%손형%손연%장굉위%리리
肺炎支原体%血清抗体%家庭%暴发
肺炎支原體%血清抗體%傢庭%暴髮
폐염지원체%혈청항체%가정%폭발
Mycoplasma pneumoniae%Serum antibodies%Family%Disease outbreaks
目的 调查一起肺炎支原体(MP)感染家庭暴发的流行病学和血清学特点.方法 了解治疗陪护期间家庭成员间的接触情况；所有成员检测血清MP抗体及胸部X线检查.结果 该家庭包括3名核心成员(男童和其父、母亲)及其外祖母和叔叔(均参与照顾男童及其父住院)共5人.23 d内先后4人发病,3人X线诊断肺炎且双份血清MP抗体滴度均呈4倍以上升高.男童的父亲和叔叔分别在发病后3d和2d检测血清MP-IgG(+).男童及其父均有重度咳嗽.外祖母暴露于男童和叔叔暴露于父亲分别只在两家医院的空调病房内.密切接触时间最长的是男童与其母(至检测时已连续密切接触37 d),但母亲无症状,血清MP-IgM(-).结论 既往感染获得的MP-IgG不能完全保护再次感染MP;指征病例有肺炎咳嗽重、长时间密切接触、环境通风不良和家庭成员普遍过度疲劳,几种危险因素并存可能是导致该起家庭MP感染暴发的原因.
目的 調查一起肺炎支原體(MP)感染傢庭暴髮的流行病學和血清學特點.方法 瞭解治療陪護期間傢庭成員間的接觸情況；所有成員檢測血清MP抗體及胸部X線檢查.結果 該傢庭包括3名覈心成員(男童和其父、母親)及其外祖母和叔叔(均參與照顧男童及其父住院)共5人.23 d內先後4人髮病,3人X線診斷肺炎且雙份血清MP抗體滴度均呈4倍以上升高.男童的父親和叔叔分彆在髮病後3d和2d檢測血清MP-IgG(+).男童及其父均有重度咳嗽.外祖母暴露于男童和叔叔暴露于父親分彆隻在兩傢醫院的空調病房內.密切接觸時間最長的是男童與其母(至檢測時已連續密切接觸37 d),但母親無癥狀,血清MP-IgM(-).結論 既往感染穫得的MP-IgG不能完全保護再次感染MP;指徵病例有肺炎咳嗽重、長時間密切接觸、環境通風不良和傢庭成員普遍過度疲勞,幾種危險因素併存可能是導緻該起傢庭MP感染暴髮的原因.
목적 조사일기폐염지원체(MP)감염가정폭발적류행병학화혈청학특점.방법 료해치료배호기간가정성원간적접촉정황；소유성원검측혈청MP항체급흉부X선검사.결과 해가정포괄3명핵심성원(남동화기부、모친)급기외조모화숙숙(균삼여조고남동급기부주원)공5인.23 d내선후4인발병,3인X선진단폐염차쌍빈혈청MP항체적도균정4배이상승고.남동적부친화숙숙분별재발병후3d화2d검측혈청MP-IgG(+).남동급기부균유중도해수.외조모폭로우남동화숙숙폭로우부친분별지재량가의원적공조병방내.밀절접촉시간최장적시남동여기모(지검측시이련속밀절접촉37 d),단모친무증상,혈청MP-IgM(-).결론 기왕감염획득적MP-IgG불능완전보호재차감염MP;지정병례유폐염해수중、장시간밀절접촉、배경통풍불량화가정성원보편과도피로,궤충위험인소병존가능시도치해기가정MP감염폭발적원인.
Objective To describe the epidemiological and serological features on a family associated outbreak caused by Mycoplasma pneumoniae (MP) infection occurred in Beijing in August 2007.Methods Mutual exposure of the family members was investigated and retrospective medical record was reviewed for the hospitalized patients.Serum antibodies to MP were measured and chest X-rays were taken for all the family members.Results This family consisted of 5 members,with fixed members as the boy (13 years old ),his father (43 years old) and mother (44 years old),grandmother (64 years old) and uncle (32 years old ) who was involved in taking care of the sick boy and his father.During 23 days of the event,four of all the five family members were ill.Three (boy,father and uncle) had radiographic pneumonia,whose paired sera all showed a ≥ fourfold increase in antibody titer,and two of them were confnrmed by chest X-ray on day 2 after onset of fever.The grandmother suffered from bronchitis,with positive(PA) serum antibody to MR Serum MP-IgG from the father and uncle was positive,3 days and 2 days after the onset of fever.The chances of contact between grandmother with the boy and uncle with the father were both only in the hospital wards.Only the mother remained asymptomatic,with her serum MP-IgM (-)and MP-IgG ( + )for which the blood sample was collected 37 days after close contact with the boy.The longest time of exposure to the patients was between mother and the boy but only the mother did not increase her total workload or feeling for fatigue.Conclusion Results of MP-IgG from post-infection did not completely defend against the repeated MP infection.Combined risk factors as index patients with severe cough,prolonged close contact,poorly ventilation of the environment,and family members with excessive fatigue might work as the causes of this family MP outbreak.
