中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2010年
12期
16-17,20
,共3页
慢性肺原性心脏病%CGRP%P物质%放射免疫分析
慢性肺原性心髒病%CGRP%P物質%放射免疫分析
만성폐원성심장병%CGRP%P물질%방사면역분석
Chronic cor pulmonale%Calcitonin gene-related peptide%Substance P%Radioimmunoassay
目的 探讨血浆降钙素基因相关肽(calcitonin gene-related peptide,CGRP)和P物质(substance P, SP)在慢性肺源性心脏病(肺心病)发生发展中的病理生理作用.方法 采用放射免疫分析法测定30例肺心病组急性发作期和治疗后缓解期及20例正常对照组血浆CGRP和SP 浓度.肺心病组同时检测动脉氧分压(PaO2).结果 血浆CGRP水平肺心病组急性发作期(12±5)pg/ml和治疗后缓解期(19±7)pg/ml均低于正常对照组(24±5)pg/ml,差异有统计学意义(P<0.01).急性发作期血浆CGRP水平低于治疗后缓解期,差异有统计学意义(P<0.01).肺心病组急性发作期血浆SP 水平(39±12)pg/ml显著低于治疗后缓解期(46±11)pg/ml和正常对照组(45±8)pg/ml(P<0.01或P<0.05).治疗后缓解期和正常对照组血浆SP水平差异无统计学意义(P>0.05).PaO2急性发作期和治疗后缓解期分别为(6.3±2.0)kPa、(9.5±1.6)kPa,差异有统计学意义(P<0.01).结论 慢性缺氧与血浆CGRP、SP水平下降有关,尤其是CGRP,缺氧时两者的变化共同促进了肺动脉高压的形成,在慢性肺源性心脏病发生发展中起重要作用.
目的 探討血漿降鈣素基因相關肽(calcitonin gene-related peptide,CGRP)和P物質(substance P, SP)在慢性肺源性心髒病(肺心病)髮生髮展中的病理生理作用.方法 採用放射免疫分析法測定30例肺心病組急性髮作期和治療後緩解期及20例正常對照組血漿CGRP和SP 濃度.肺心病組同時檢測動脈氧分壓(PaO2).結果 血漿CGRP水平肺心病組急性髮作期(12±5)pg/ml和治療後緩解期(19±7)pg/ml均低于正常對照組(24±5)pg/ml,差異有統計學意義(P<0.01).急性髮作期血漿CGRP水平低于治療後緩解期,差異有統計學意義(P<0.01).肺心病組急性髮作期血漿SP 水平(39±12)pg/ml顯著低于治療後緩解期(46±11)pg/ml和正常對照組(45±8)pg/ml(P<0.01或P<0.05).治療後緩解期和正常對照組血漿SP水平差異無統計學意義(P>0.05).PaO2急性髮作期和治療後緩解期分彆為(6.3±2.0)kPa、(9.5±1.6)kPa,差異有統計學意義(P<0.01).結論 慢性缺氧與血漿CGRP、SP水平下降有關,尤其是CGRP,缺氧時兩者的變化共同促進瞭肺動脈高壓的形成,在慢性肺源性心髒病髮生髮展中起重要作用.
목적 탐토혈장강개소기인상관태(calcitonin gene-related peptide,CGRP)화P물질(substance P, SP)재만성폐원성심장병(폐심병)발생발전중적병리생리작용.방법 채용방사면역분석법측정30례폐심병조급성발작기화치료후완해기급20례정상대조조혈장CGRP화SP 농도.폐심병조동시검측동맥양분압(PaO2).결과 혈장CGRP수평폐심병조급성발작기(12±5)pg/ml화치료후완해기(19±7)pg/ml균저우정상대조조(24±5)pg/ml,차이유통계학의의(P<0.01).급성발작기혈장CGRP수평저우치료후완해기,차이유통계학의의(P<0.01).폐심병조급성발작기혈장SP 수평(39±12)pg/ml현저저우치료후완해기(46±11)pg/ml화정상대조조(45±8)pg/ml(P<0.01혹P<0.05).치료후완해기화정상대조조혈장SP수평차이무통계학의의(P>0.05).PaO2급성발작기화치료후완해기분별위(6.3±2.0)kPa、(9.5±1.6)kPa,차이유통계학의의(P<0.01).결론 만성결양여혈장CGRP、SP수평하강유관,우기시CGRP,결양시량자적변화공동촉진료폐동맥고압적형성,재만성폐원성심장병발생발전중기중요작용.
Objective To evaluate the pathophysiological role of calcitonin gene-related peptide(CGRP) and substance P(SP) in patients with chronic cor pulmonale. Methods The levels of plasma CGRP and SP were determined by radioimmunoassay in 30 patients with chronic cor pulmonale before and after treatment, and their mean pulmonary aterial pressure(PaO2) were detected. Control group consisted of 20 healthy subjects and the levels of plasma CGRP and cor pulmonale group, plasma CGRP levels before treatment(12±5 pg/ml)were lower than those after treatment(19±7)pg/ml(P<0.01). Both of them were lower than those in control group(24±5)pg/ml(P<0.01). Plasma SP levels before treatment(39±12)pg/ml were significantly lower than those after treatment(46±11)pg/ml (P<0.01), and control group(45±8)pg/ml(P<0.05), and there after treatment in chronic cor pulmonale group, PaO2 were (6.3±2.0)kPa and (9.5±1.6)kPa respectively, the former was significantly lower than the latter(P<0.01). Conclusions This study suggests that hypoxia has a statistical relationship with the decrease of plasma CGRP and SP levels in patients with chronic cor pulmonale, particularly with CGRP, and the decrease of plasma CGRP and SP levels may contribute to the development of hypoxia pulmonary hypertension and play an important part in the pathophysiological changes of chronic cor pulmonale.
