食用菌学报
食用菌學報
식용균학보
ACTA EDULIS FUNGI
2006年
2期
15-28
,共14页
张劲松%唐庆九%ZIMMERMAN-KORDMANN Martin%REUTTER Werner%樊华
張勁鬆%唐慶九%ZIMMERMAN-KORDMANN Martin%REUTTER Werner%樊華
장경송%당경구%ZIMMERMAN-KORDMANN Martin%REUTTER Werner%번화
灵芝%凋亡%肿瘤细胞
靈芝%凋亡%腫瘤細胞
령지%조망%종류세포
Ganoderma lucidum%Apoptosis%Tumor cells
灵芝水提物(LZ)对8种肿瘤细胞增殖的抑制作用具有剂量依赖关系.通过透析和离子交换凝胶过滤层析方法从LZ中分离出活性组分LZ-DN-2-2和LZ-DW-2-a-3.LZ、LZ-DN-2-2 和LZ-DW-2-a-3可剂量依赖地诱导SW620细胞凋亡,使细胞增殖周期停滞于G0期.
靈芝水提物(LZ)對8種腫瘤細胞增殖的抑製作用具有劑量依賴關繫.通過透析和離子交換凝膠過濾層析方法從LZ中分離齣活性組分LZ-DN-2-2和LZ-DW-2-a-3.LZ、LZ-DN-2-2 和LZ-DW-2-a-3可劑量依賴地誘導SW620細胞凋亡,使細胞增殖週期停滯于G0期.
령지수제물(LZ)대8충종류세포증식적억제작용구유제량의뢰관계.통과투석화리자교환응효과려층석방법종LZ중분리출활성조분LZ-DN-2-2화LZ-DW-2-a-3.LZ、LZ-DN-2-2 화LZ-DW-2-a-3가제량의뢰지유도SW620세포조망,사세포증식주기정체우G0기.
A crude aqueous extract of Ganoderma lucidum fruiting bodies, LZ, inhibited the growth of eight different tumor cell lines in a dose-dependent manner. Two bioactive fractions, LZ-DN-2-2 and LZ-DW-2-a-3, were obtained from LZ using dialysis combined with anion exchange and gel filtration chromatography. LZ, LZ-DN-2-2 and LZ-DW-2-a-3 induced apoptosis of SW620 cells in a dose-dependent manner, and arrested the tumor cells in the G0 phase of the cell cycle.
