中国循环杂志
中國循環雜誌
중국순배잡지
CHINESE CIRCULATION JOURNAL
2009年
5期
325-328
,共4页
张春艳%王聪霞%张岩%董新%党寅虎%朱参战%韩振华%段宗明%李永勤
張春豔%王聰霞%張巖%董新%黨寅虎%硃參戰%韓振華%段宗明%李永勤
장춘염%왕총하%장암%동신%당인호%주삼전%한진화%단종명%리영근
非ST段抬高急性冠脉综合征%N末端脑钠肽%基质金属蛋白酶9%心室重构
非ST段抬高急性冠脈綜閤徵%N末耑腦鈉肽%基質金屬蛋白酶9%心室重構
비ST단태고급성관맥종합정%N말단뇌납태%기질금속단백매9%심실중구
Non-ST elevation acute coronary syndrome%N-terminal probrain natriuretic peptide%Matrix metalloproteinase-9%Ven-tricular remodeling
目的:探讨N末端脑钠肽(NT-proBNP)及基质金属蛋白酶-9(MMP-9)在判断非ST段抬高急性冠脉综合征早期心室重构中的作用及相互关系. 方法:选择连续住院的非ST段抬高急性冠脉综合征患者57例,分为高危组(n=17)、中危组(n=15)及低危组(n=25),并设正常对照组(n=29).冠状动脉造影前抽取股动脉血,测定NT-proBNP及MMP-9浓度.分别于造影前后3天内及造影后10～14天内行超声心动图检查. 结果:各组间NT-proBNP、MMP-9水平及射血分数、左心室质量指数(LVMI)差异具有统计学意义(除射血分数在中危组和低危组之间P>0.05外,其余P均<0.05).在高危组,NT-proBNP与MMP-9呈正相关(r=0.574,P=0.025),NT-proBNP与LVMI呈正相关(r=0.617,P=0.014);MMP-9与射血分数呈负相关(r=-0.542,P=O.025). 结论:联合检测NT-proBNP及MMP-9对判定高危非ST段抬高急性冠脉综合征早期心室重构具有重要意义.
目的:探討N末耑腦鈉肽(NT-proBNP)及基質金屬蛋白酶-9(MMP-9)在判斷非ST段抬高急性冠脈綜閤徵早期心室重構中的作用及相互關繫. 方法:選擇連續住院的非ST段抬高急性冠脈綜閤徵患者57例,分為高危組(n=17)、中危組(n=15)及低危組(n=25),併設正常對照組(n=29).冠狀動脈造影前抽取股動脈血,測定NT-proBNP及MMP-9濃度.分彆于造影前後3天內及造影後10～14天內行超聲心動圖檢查. 結果:各組間NT-proBNP、MMP-9水平及射血分數、左心室質量指數(LVMI)差異具有統計學意義(除射血分數在中危組和低危組之間P>0.05外,其餘P均<0.05).在高危組,NT-proBNP與MMP-9呈正相關(r=0.574,P=0.025),NT-proBNP與LVMI呈正相關(r=0.617,P=0.014);MMP-9與射血分數呈負相關(r=-0.542,P=O.025). 結論:聯閤檢測NT-proBNP及MMP-9對判定高危非ST段抬高急性冠脈綜閤徵早期心室重構具有重要意義.
목적:탐토N말단뇌납태(NT-proBNP)급기질금속단백매-9(MMP-9)재판단비ST단태고급성관맥종합정조기심실중구중적작용급상호관계. 방법:선택련속주원적비ST단태고급성관맥종합정환자57례,분위고위조(n=17)、중위조(n=15)급저위조(n=25),병설정상대조조(n=29).관상동맥조영전추취고동맥혈,측정NT-proBNP급MMP-9농도.분별우조영전후3천내급조영후10～14천내행초성심동도검사. 결과:각조간NT-proBNP、MMP-9수평급사혈분수、좌심실질량지수(LVMI)차이구유통계학의의(제사혈분수재중위조화저위조지간P>0.05외,기여P균<0.05).재고위조,NT-proBNP여MMP-9정정상관(r=0.574,P=0.025),NT-proBNP여LVMI정정상관(r=0.617,P=0.014);MMP-9여사혈분수정부상관(r=-0.542,P=O.025). 결론:연합검측NT-proBNP급MMP-9대판정고위비ST단태고급성관맥종합정조기심실중구구유중요의의.
Objective:To evaluate the value and correlation of N-terminal probrain natriuretic peptide( NT-proBNP)and Matrix Metallo-proteinase-9(MMP-9)in early ventricular remodeling in non-ST elevation acute coronary syndrome (ACS). Methods:A total of 57 consecutive patients with non-ST elevation ACS were recruited and classified in 3 groups:High risk group (n = 17) ,Intermediate risk group (n = 15) and Low risk group (n =25) ; in addition, 29 healthy individuals were served as Control group. The levels of serum NT-proBNP and MMP-9 were respectively examined before coronary angiogra-phy. Echocardiogram was performed before and after the angiography to evaluate the ventricular remodeling and heart function. Results:There were significant differences between the levels of NT-proBNP,MMP-9,the values of ejection fraction (EF) and left ventricular mass index ( LVMI) in different groups, while not much difference was found in EF between Intermediate risk group and Low risk group. In High-risk group,NT-proBNP level was positively related to MMP-9 concentration(r =0.574,P = 0.025 ) ;NT-proBNP level was positively related to LVMI value( r = 0. 617 ,P = 0. 014) ;MMP-9 level was negatively related to EF value(r= -0.542,P =0.025). Conclusion: The combination testing of NT-proBNP and MMP-9 had crucial meaning for detection of early ventricular remod-eling in high-risk non-ST elevation ACS.
