CAJ | 학술논문

自噬是细胞内降解细胞成分的主要通道,对生物体的生存、分化、发育和维持其动态平衡具有关键作用.自噬机制既可作为免疫系统清除细胞内病原物质的效应器,也可作为模式识别受体或细胞因子的效应器,帮助免疫系统确认病原侵入和细胞转化.更为重要的是,自噬过程还可通过将细胞内物质转移到溶酶体降解并呈递给Ⅱ型MHC分子,与细胞应激和炎症反应耦联,参与调节固有免疫和适应性免疫反应.对自噬参与免疫反应分子机制的研究将加深对免疫反应分子机制的全面了解,为自噬相关疾病防治提供新的机会和途径.
자서시세포내강해세포성분적주요통도,대생물체적생존、분화、발육화유지기동태평형구유관건작용.자서궤제기가작위면역계통청제세포내병원물질적효응기,야가작위모식식별수체혹세포인자적효응기,방조면역계통학인병원침입화세포전화.경위중요적시,자서과정환가통과장세포내물질전이도용매체강해병정체급Ⅱ형MHC분자,여세포응격화염증반응우련,삼여조절고유면역화괄응성면역반응.대자서삼여면역반응분자궤제적연구장가심대면역반응분자궤제적전면료해,위자서상관질병방치제공신적궤회화도경.
Autophagy is a major pathway for degradation of cellular components and it contributes to the survival, differentiation, development, and dynamic homeostasis of organisms. Recent studies have demonstrated that autophagic mechanisms act as the effectors of immune systems, pattern recognition receptors and cy-tokines to clean the invasive pathogens in the cells. It was also found that immune systems recognize the invasive pathogens via monitoring the autophagic products. This pathway delivers the cytoplasmic material for lysosomal hydrolysis and presents the antigens to MHC Ⅱ molecules so as to activate the CD4 + T cells. Importantly, autophagy can couple with signaling for stress responses of cells and/or inflammatory responses to function as a defense. This paper reviewed the advance of rapidly developing research field and introduced the molecular mechanisms that autophagy regulates innate and adaptive immunity. These studies will deepen our understanding the mechanisms of immune responses and may provide a novel therapeutic strategy for autophage-associated diseases.