中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2009年
2期
1-3
,共3页
吴燕峰%陈纯%王潇娉%张碧红
吳燕峰%陳純%王瀟娉%張碧紅
오연봉%진순%왕소빙%장벽홍
HLA-Cw配型%异基因%造血干细胞移植%移植物抗宿主病
HLA-Cw配型%異基因%造血榦細胞移植%移植物抗宿主病
HLA-Cw배형%이기인%조혈간세포이식%이식물항숙주병
HLA-Cw typing%Allogeneic%Hematopoietic stem cell transplantation%Graft-versus-host disease
目的 探讨HLA-Cw配型在异基因造血干细胞移植中与GVHD的发生和复发的关系.方法 对HLA 6个位点(A、B、DR/DQ)全相合的同胞供者9例异基因外周血干细胞移植和10例脐带血移植进一步进行HLA-Cw配型,分析HLA-Cw配型与GVHD发生的关系.结果 16例HLA-Cw相合者,共植入15例(94%),其中Ⅰ～Ⅱ度急性GVHD发生11例(69%),Ⅲ度急性GVHD 2例(12.5%),慢性GVHD15例(94%),无复发病例.在HLA-Cw不相合3例中,2例发生Ⅲ度GVHD并且早期死亡,1例早期复发.在HLA-Cw配型相合与不相合两组间,急性Ⅰ～Ⅱ度及Ⅲ度GVHD的发生其差异均具有统计学意义(P<0.05).结论 HLA-Cw配型相合供体造血干细胞移植有利于减少植入后急性GVHD发生及复发,提示HLA-Cw位点配型在造血干细胞移植,尤其是异基因移植中具有重要意义.
目的 探討HLA-Cw配型在異基因造血榦細胞移植中與GVHD的髮生和複髮的關繫.方法 對HLA 6箇位點(A、B、DR/DQ)全相閤的同胞供者9例異基因外週血榦細胞移植和10例臍帶血移植進一步進行HLA-Cw配型,分析HLA-Cw配型與GVHD髮生的關繫.結果 16例HLA-Cw相閤者,共植入15例(94%),其中Ⅰ～Ⅱ度急性GVHD髮生11例(69%),Ⅲ度急性GVHD 2例(12.5%),慢性GVHD15例(94%),無複髮病例.在HLA-Cw不相閤3例中,2例髮生Ⅲ度GVHD併且早期死亡,1例早期複髮.在HLA-Cw配型相閤與不相閤兩組間,急性Ⅰ～Ⅱ度及Ⅲ度GVHD的髮生其差異均具有統計學意義(P<0.05).結論 HLA-Cw配型相閤供體造血榦細胞移植有利于減少植入後急性GVHD髮生及複髮,提示HLA-Cw位點配型在造血榦細胞移植,尤其是異基因移植中具有重要意義.
목적 탐토HLA-Cw배형재이기인조혈간세포이식중여GVHD적발생화복발적관계.방법 대HLA 6개위점(A、B、DR/DQ)전상합적동포공자9례이기인외주혈간세포이식화10례제대혈이식진일보진행HLA-Cw배형,분석HLA-Cw배형여GVHD발생적관계.결과 16례HLA-Cw상합자,공식입15례(94%),기중Ⅰ～Ⅱ도급성GVHD발생11례(69%),Ⅲ도급성GVHD 2례(12.5%),만성GVHD15례(94%),무복발병례.재HLA-Cw불상합3례중,2례발생Ⅲ도GVHD병차조기사망,1례조기복발.재HLA-Cw배형상합여불상합량조간,급성Ⅰ～Ⅱ도급Ⅲ도GVHD적발생기차이균구유통계학의의(P<0.05).결론 HLA-Cw배형상합공체조혈간세포이식유리우감소식입후급성GVHD발생급복발,제시HLA-Cw위점배형재조혈간세포이식,우기시이기인이식중구유중요의의.
Objective To determine the effects of HLA-Cw typing on graft-versus-host disease and re-lapse after allogeneic hematopoietic stem cell transplantation. Methods HLA - Cw typing was performed in HLA identical allogeneic hematopoietic stem cell transplantation,including 9 patients with allogeneic peripheral blood stem cell transplantation(allo-PBSCT) and 10 patients with umbilical cord blood(UCBT) respectively. A-cute GVHD data were compared between the groups with different HLA-Cw typing results (matched and un-matched). Results In 16 HLA-Cw matched patients,15 cases got engrafted(94%) ,and 11 patients had Ⅰ～Ⅱ acute GVHD and 2 patients had Ⅲ acute GVHD. Fifteen patients had chronic GVHD but no patients had re-lapse. In 3 HLA-Cw unmatched patients,2 patients had Ⅲ acute GVHD and died in early stage and 1 patient had early relapse. When cases were classified into two groups accoring to HLA-Cw typing results, there is statisti-cally significant difference in both Ⅰ～Ⅱ and Ⅲ acute GVHD between these two groups (P < 0. 05). Conclu-sion In hematopoietic stem cell transplantation cases, HLA-Cw matching may be helpful to reduce GVHD. The results suggest that HLA typing is important for the prognosis of hematopoietic stem cell transplantation in addi-tion to HLA-A, B, DR/DQ matching.
