CAJ | 학술논문

目的探讨载脂蛋白E(apoE)基因多态性与胆石病的关系.方法全面检索和筛选相关文献,通过Meta分析的方法对各研究结果进行数据合并,并评价其发表偏倚,运用敏感性分析评价结果的可靠性.结果检索到相关文献11篇,包括1248例胆石病患者,1660例对照组.Meta分析研究发现,apoE等位基因ε4 以及基因型E3/E4在胆石病患者中的分布频率明显高于对照组.其合并0R值及95%的CJ(可信区间)分别是1.32(1.01～1.71)、1.60(1.04～2.46),P<0.05.发表性偏倚和敏感性分析显示部分存在发表偏倚,但稳定性较好.结论胆石病与apoE基因的多态性密切相关,等位基因ε4以及基因型E3/E4是胆石病的危险因子.
목적 탐토재지단백E(apoE)기인다태성여담석병적관계.방법 전면검색화사선상관문헌,통과Meta분석적방법대각연구결과진행수거합병,병평개기발표편의,운용민감성분석평개결과적가고성.결과 검색도상관문헌11편,포괄1248례담석병환자,1660례대조조.Meta분석연구발현,apoE등위기인ε4 이급기인형E3/E4재담석병환자중적분포빈솔명현고우대조조.기합병0R치급95%적CJ(가신구간)분별시1.32(1.01～1.71)、1.60(1.04～2.46),P<0.05.발표성편의화민감성분석현시부분존재발표편의,단은정성교호.결론 담석병여apoE기인적다태성밀절상관,등위기인ε4이급기인형E3/E4시담석병적위험인자.
Objective To evaluate the relationship between apoE gene polymorphisms and gallstone. Methods We included all the published studies on the association between apoE gene polymorphisms and gall-stone. A meta-analysis was employed to summarize all these studies, calculate the pooled OR and its 95% confidence interval (95% CI) , and test the overall effects. The Egger's publication bias analysis and sensitivity analysis were carried out to evaluate the reliability and stability of the meta-analysis. Results Eleven association studies between the apoE gene polymorphisms and gallstone fulfilled our inclusion criteria. There were 1248 patients with gallstones and 1660 controls. Remarkable heterogeneities were discovered in the allele ε4 and genotype E3/E4 of apoE between gallstone and control subjects in these studies (P<0. 05). Their ORs and 95%CIs were 1.32 (1.01, 1. 71), 1. 60 (1. 04, 2. 46), respectively (P<0. 05). The results of sensitivity analysis and publication bias analysis showed the reliability and stability of this meta-analysis. Conclusion apoE gene polymorphisms are associated with gallstone. Those with the alleleε4 or genotype E3 /E4 had a higher risk of suffering from gallstone.