中国医药工业杂志
中國醫藥工業雜誌
중국의약공업잡지
CHINESE JOURNAL OF PHARMACEUTICALS
2001年
5期
217-219
,共3页
沈卫镝%姚建忠%方勇%许德余
瀋衛鏑%姚建忠%方勇%許德餘
침위적%요건충%방용%허덕여
光动力效应%紫红素-18%光敏化力%肿瘤抑制率
光動力效應%紫紅素-18%光敏化力%腫瘤抑製率
광동력효응%자홍소-18%광민화력%종류억제솔
对叶绿素a降解产物紫红素-18(1)在非细胞体系中的光敏化力和对小鼠肉瘤-180的光动力治疗作用进行了研究。结果表明，1在D2O中对NADPH的光氧化作用的敏化效应明显高于参比药物血卟啉衍生物(HpD)；其4 mg/kg时肿瘤抑制率可达95.1%，疗效较HpD显著(P<0.01)。
對葉綠素a降解產物紫紅素-18(1)在非細胞體繫中的光敏化力和對小鼠肉瘤-180的光動力治療作用進行瞭研究。結果錶明，1在D2O中對NADPH的光氧化作用的敏化效應明顯高于參比藥物血卟啉衍生物(HpD)；其4 mg/kg時腫瘤抑製率可達95.1%，療效較HpD顯著(P<0.01)。
대협록소a강해산물자홍소-18(1)재비세포체계중적광민화력화대소서육류-180적광동력치료작용진행료연구。결과표명，1재D2O중대NADPH적광양화작용적민화효응명현고우삼비약물혈계람연생물(HpD)；기4 mg/kg시종류억제솔가체95.1%，료효교HpD현저(P<0.01)。
The sensitizing effect of purpurin-18 on photooxidation of NADPH in deuterium oxide and its photodynamic effect on sarcoma 180 in mice in different doses and at different intervals between injection and irradiation were investigated.It was found that the photosensitizing effect of purpurin-18 was much higher than that of the reference drug hematoporphyrin derivative (HpD).The tumor inhibition rate of purpurin-18 at the dose of 4 mg/kg was 95.1%,significantly different from HpD (P<0.01).
