CAJ | 학술논문

为了探讨Meynert基底核内促肾上腺皮质激素释放因子对学习记忆的影响,本实验采用脑内埋管微量注射技术,把促肾上腺皮质激素释放因子(0, 0.01, 0.1和0.4 nmol四个剂量组)分别注入大鼠双侧的Meynert基底核内,采用Morris水迷宫对大鼠进行空间辨别性学习记忆能力的测试.结果发现:0.1和0.4 nmol剂量促肾上腺皮质激素释放因子均能使大鼠训练时寻找平台的时间(逃避潜伏期)延长,第12 d的空间探索试验,0.1和0.4 nmol剂量组的大鼠找到平台的时间也显著延长.结果提示:促肾上腺皮质激素释放因子在Meynert基底核内可损害大鼠的空间辨别性学习能力和记忆的巩固.
위료탐토Meynert기저핵내촉신상선피질격소석방인자대학습기억적영향,본실험채용뇌내매관미량주사기술,파촉신상선피질격소석방인자(0, 0.01, 0.1화0.4 nmol사개제량조)분별주입대서쌍측적Meynert기저핵내,채용Morris수미궁대대서진행공간변별성학습기억능력적측시.결과발현:0.1화0.4 nmol제량촉신상선피질격소석방인자균능사대서훈련시심조평태적시간(도피잠복기)연장,제12 d적공간탐색시험,0.1화0.4 nmol제량조적대서조도평태적시간야현저연장.결과제시:촉신상선피질격소석방인자재Meynert기저핵내가손해대서적공간변별성학습능력화기억적공고.
The present study was performed to explore the role of corticotropin releasing factor (CRF) in the nucleus basalis of Meynert (NBM) in spatial learning and memory of rats. The latency, distance and swimming path to find the platform were measured by Morris water maze after intra-NBM injections of 0, 0.01, 0.1 and 0.4 nmol of CRF. Intra-NBM injections of 0.1 or 0.4 nmol of CRF induced significant increase of the latency for spatial learning and memory, and there were no significant changes in the swimming speed in Morris water maze test. The results suggest that CRF plays an inhibitory role in spatial learning and memory consolidation in the NBM of rats.