CAJ | 학술논문

目的探讨慢性乙肝患者血清生化指标与肝组织病理学炎症及纤维化程度的关系.方法常规测定197例慢性乙肝患者血清总胆红素(TBL)、丙氨酸氨基转移酶(ALT)、白蛋白(ALB)、凝血酶原活动度(PTA)、白蛋白/球蛋白比值(A/G),同时行肝穿刺活组织检查,进行组织病理学炎症分级和纤维化分期.分析血清生化指标与肝组织病理改变的相关性.结果轻度慢性肝炎时,血生化检查单项指标与病理诊断符合率为51.1%～91.3%,尤以ALB符合率较高.重度慢性肝炎以TBIL、ALB、PTA作为标准符合率较高,分别为92.6%,62.9%和59.3%.结论生化指标检测一定程度上能反映肝脏的炎症和纤维化程度.但单靠血生化指标或肝脏一点穿刺活检确定病情程度有一定误差,应对各项指标综合分析,动态观察.
목적 탐토만성을간환자혈청생화지표여간조직병이학염증급섬유화정도적관계.방법 상규측정197례만성을간환자혈청총담홍소(TBL)、병안산안기전이매(ALT)、백단백(ALB)、응혈매원활동도(PTA)、백단백/구단백비치(A/G),동시행간천자활조직검사,진행조직병이학염증분급화섬유화분기.분석혈청생화지표여간조직병리개변적상관성.결과 경도만성간염시,혈생화검사단항지표여병리진단부합솔위51.1%～91.3%,우이ALB부합솔교고.중도만성간염이TBIL、ALB、PTA작위표준부합솔교고,분별위92.6%,62.9%화59.3%.결론 생화지표검측일정정도상능반영간장적염증화섬유화정도.단단고혈생화지표혹간장일점천자활검학정병정정도유일정오차,응대각항지표종합분석,동태관찰.
Objective To investigate the relationship among serum biochemical indicators and liver histopathological inflammation and fibrosis degree in patients with chronic hepatitis B.Methods The serum total bilirubin (TBIL),alanine aminotransferase (ALT),albumin (ALB),prothrombin activity (PTA) and albumin/globulin ratio (A/G) of 197 cases of chronic hepatitis B were detected,and the liver puncture biopsy was performed to get the histopathological grading of inflammation and fibrosis.The relationship between serum biochemical indicators and liver histopathological changes was analyzed.Results With mild chronic hepatitis,the coincidence of single serum biochemical index,ALB particularly,and pathological diagnosis were 51.1%～91.3%;With severe chronic hepatitis,the coincidence of TBIL,ALB and PTA and pathological diagnosis were 92.6%,62.9% and 59.3% respectively.Conclusions The detection of biochemical indicator was to some extent able to reflect liver inflammation and fibrosis to some extent.But there may be some degree of error if only detecting blood biochemieal indicators or liver biopsy.The different detecting indexes should be comprehensive analyzed and dynamic observed.