CAJ | 학술논문

Livin是凋亡抑制蛋白家族的新成员,在多种肿瘤中高表达,与肿瘤的发生、发展、治疗及预后密切相关.多种研究证明,RNA干扰Livin后能抑制肿瘤生长,促进肿瘤细胞凋亡,并能增强肿瘤细胞对放化疗的敏感性.Livin在caspases的作用下发生裂解,产生的缩短片段具有促进肿瘤细胞凋亡的作用,为肿瘤治疗提供了新的方向.
Livin시조망억제단백가족적신성원,재다충종류중고표체,여종류적발생、발전、치료급예후밀절상관.다충연구증명,RNA간우Livin후능억제종류생장,촉진종류세포조망,병능증강종류세포대방화료적민감성.Livin재caspases적작용하발생렬해,산생적축단편단구유촉진종류세포조망적작용,위종류치료제공료신적방향.
Livin,a novel member of human inhibitor of apoptosis protein family,is highly expressed in various malignant tumors. It plays an important role in the initiation,development,treatment and prognosis of tumors.Many studies have proved that down-regulation of Livin expression using RNA interference technique can reduce tumor growth,increase the apoptotic rate,and sensitize tumor cells to radiotherapy and chemo therapy.Full-length Livin is cleaved by the effector caspases to produce a truncated form (tLivin) with apoptosis-promotion activity.tLivin provides a new direction for the treatment of the malignant tumors.