CAJ | 학술논문

P53蛋白在抑制肿瘤形成方面发挥着至关重要的作用,当细胞出现DNA损伤、癌基因激活或者应激时P53蛋白就会在细胞中大量集聚.它作为一个核转录因子能够反式激活与细胞凋亡、细胞周期控制及一系列过程相关的基因.最新研究揭示核外P53有触发凋亡和抑制自噬的作用.这些作用有助于P53发挥其抑癌功能.新的有关P53在核外功能的研究对进一步了解P53在肿瘤发生发展中的作用机制具有重要意义.
P53단백재억제종류형성방면발휘착지관중요적작용,당세포출현DNA손상、암기인격활혹자응격시P53단백취회재세포중대량집취.타작위일개핵전록인자능구반식격활여세포조망、세포주기공제급일계렬과정상관적기인.최신연구게시핵외P53유촉발조망화억제자서적작용.저사작용유조우P53발휘기억암공능.신적유관P53재핵외공능적연구대진일보료해P53재종류발생발전중적작용궤제구유중요의의.
P53 protein plays a crucial role in inhibition tumor development.It will accumulate in cells in the condition of DNA damage,oncogenes activation or stress.As a nuclear transcription factor,P53 can transactivate the genes which correlate with apoptosis,cell cycle control and other procedures. Current research reveals P53 outside the nucleus can induce apoptosis and inhibit autophagy which contributes to its function of tumor suppression.The study of the extranuclear function of P53 is beneficial to further understanding the mechanism of P53 in the genesis and development of tumor.