CAJ | 학술논문

生殖器疱疹主要是由2型人类单纯疱疹病毒引起的性传播疾病.在动物阴道内注射病毒液可以建立生殖器疱疹动物模型,在此基础上还可以进一步建立复发感染模型.利用雌性豚鼠建立生殖器疱疹动物模型对于需要观察皮损变化方面的药效学等研究是较为理想的选择.通过观察豚鼠/小鼠外阴及阴道皮损病变情况并进行评分可以用于生殖器疱疹发病机制的研究,还可以用于抗疱疹病毒新药和疫苗的研究.
생식기포진주요시유2형인류단순포진병독인기적성전파질병.재동물음도내주사병독액가이건립생식기포진동물모형,재차기출상환가이진일보건립복발감염모형.이용자성돈서건립생식기포진동물모형대우수요관찰피손변화방면적약효학등연구시교위이상적선택.통과관찰돈서/소서외음급음도피손병변정황병진행평분가이용우생식기포진발병궤제적연구,환가이용우항포진병독신약화역묘적연구.
Genital herpes is a kind of sexually transmitted disease mainly caused by herpes simplex virus type 2(HSV-2). Injecting virus into the vagina of animals is a common method to establish animal models of genital herpes, which can be used as a basis for the building of recurrent infection models. It is an ideal option to set up animal models of genital herpes by using femal guinea pigs for the observation of drug efficacy in skin lesions. To assess the lesion changes in vulva and vagina of guinea pigs or mice after the inoculation by a scoring method may be used to study the pathogenesis of genital herpes and to develop new antiviral agents and vaccines.