CAJ | 학술논문

目的探讨采用面罩储雾罐方式给药,经鼻吸入布地奈德(BUD)气雾剂同步治疗小儿变应性鼻炎并哮喘的临床疗效与成本.方法将72例中～重度变应性鼻炎并轻一中度持续性哮喘的患儿随机分为实验组和对照组,实验组经面罩储雾罐鼻吸入BUD气雾剂400g/d,对照组经口吸入BUD干粉剂400μg/d联合使用BUD鼻喷雾剂256μg/d.进行哮喘和鼻炎的症状评分,监测第1秒时间肺活量(FEV1)、晨起呼气峰流速值(PEF),并进行治疗成本比较.结果经过12周的临床观察,实验组和对照组的鼻炎症状评分明显下降(F=6.529和7.014,P均<0.01),两组的哮喘症状评分不断减低(F=4.132和4.950,P均<0.01),实验组和对照组的肺通气功能指标PEF(L/min)逐渐升高(F=2.750和3.282,P均<0.05).但两组间的症状评分、FEV1和PEF在入选时与治疗后的多次随访中比较,差异无统计学意义.实验组鼻腔干燥等副反应的发生率(5.6%)低于对照组(19.4%),但差异无统计学意义.平均治疗费用:实验组(244.0±12.8)元,对照组(403.2±17.6)元,差异有统计学意义(P<0.01).结论面罩式储雾罐经鼻吸入糖皮质激素可同时有效控制小儿变应性鼻炎和哮喘,并有依从性高、副作用少、花费低等优点,适用于轻～中度持续性哮喘合并变应性鼻炎患儿.
목적 탐토채용면조저무관방식급약,경비흡입포지내덕(BUD)기무제동보치료소인변응성비염병효천적림상료효여성본.방법 장72례중～중도변응성비염병경일중도지속성효천적환인수궤분위실험조화대조조,실험조경면조저무관비흡입BUD기무제400g/d,대조조경구흡입BUD간분제400μg/d연합사용BUD비분무제256μg/d.진행효천화비염적증상평분,감측제1초시간폐활량(FEV1)、신기호기봉류속치(PEF),병진행치료성본비교.결과 경과12주적림상관찰,실험조화대조조적비염증상평분명현하강(F=6.529화7.014,P균<0.01),량조적효천증상평분불단감저(F=4.132화4.950,P균<0.01),실험조화대조조적폐통기공능지표PEF(L/min)축점승고(F=2.750화3.282,P균<0.05).단량조간적증상평분、FEV1화PEF재입선시여치료후적다차수방중비교,차이무통계학의의.실험조비강간조등부반응적발생솔(5.6%)저우대조조(19.4%),단차이무통계학의의.평균치료비용:실험조(244.0±12.8)원,대조조(403.2±17.6)원,차이유통계학의의(P<0.01).결론 면조식저무관경비흡입당피질격소가동시유효공제소인변응성비염화효천,병유의종성고、부작용소、화비저등우점,괄용우경～중도지속성효천합병변응성비염환인.
Objective To assess the effixacy of a nasally inhaled corticosteroid(ICS) through a spacer with mask aiming at simultaneou treatment of allergic rhinitis and asthma in children and make an analysis on the costs.Method A total of 72 children with allergic rhinitis (AR) and asthma were randomized into two groups.Experimental group received budesonide inhaler(400 μg/d) through the nose using a spacer attached to a face mask,control group children orally inhaled budesonide dry powder (400μg/d) plus a nasal spray of budesonide aquae(256μg/d).Result The patients were obsenred for 12 weeks.The symptom scores of rhinitis of both experimental group and control group declined(F=6.529 and 7.014,all P<0.01),symptom scores of asthma in both group were also reduced(F=4.132 and 4.950,P<0.01).The pulmonary function PEF(L/win)in both groups continuously increased(F=2.750 and 3.282,P<0.05).But the clinical scores,PEF value and FEVl all did not differ between the two groups at admission or at nearly all follow-up visits(P>0.05 for all).The proportion of dry nose was lower in experimental group than in the control group(5.6% vs.19.4%),but the difference was not statistically significant.The cost in the experimental group was lower than that in the control group(P<0.01).Condusion Nasal inhalation of ICS provides a therapeutic strategy for controlling AR and asthula in children,especially it result in higher compliance,lower costs,and fewer side effects.