中华全科医师杂志
中華全科醫師雜誌
중화전과의사잡지
CHINESE JOURNAL OF GENERAL PRACTITIONERS
2011年
10期
737-739
,共3页
人体质量指数%非酒精性脂肪性肝病
人體質量指數%非酒精性脂肪性肝病
인체질량지수%비주정성지방성간병
Body mass index%Nonalcoholic fatty liver disease
对我院健康体检中心311例新诊断2型糖尿病患者及从既往无糖尿病病史且糖耐量正常的体检者中随机选取的366例体检者（对照组），进行病史询问、体检及血糖、肝肾功能、血脂、腹部彩色超声等检查，分析其非酒精性脂肪性肝病( NAFLD)患病情况。结果 显示，对照组366例共检出NAFLD 67例（患病率18.3％），其中轻度51例（患病率13.9％），中度15例(4.1％)，重度1例(0.3％)。311例新诊断的2型糖尿病患者中共检出NAFLD 144例（患病率46.3％），其中轻度85例（患病率27.3％），中度53例(17.0％)，重度6例(1.9％)。糖尿病患者体重指数(BMI) ＜23.0kg/m2组、23.0～24.9 kg/m2组和25.0 ～ 29.9 kg/m2组中NAFLD患病率及轻中重度脂肪肝患病率明显高于对照组（均P ＜0.01）；当BMI≥30 kg/m2时，两组NAFLD患病率差异无统计学意义(P＞0.05)。两组NAFLD的患病率均随BMI的增加而升高，当BMI≥25.0 kg/m2时升高最为明显，明显高于BMI ＜25 kg/m2者(P＜0.01)。且随着BMI的增加，2型糖尿病患者合并代谢综合征的患病率亦明显升高。提示，2型糖尿病患者NAFLD患病率较高，伴肥胖患者更易发生NAFLD。
對我院健康體檢中心311例新診斷2型糖尿病患者及從既往無糖尿病病史且糖耐量正常的體檢者中隨機選取的366例體檢者（對照組），進行病史詢問、體檢及血糖、肝腎功能、血脂、腹部綵色超聲等檢查，分析其非酒精性脂肪性肝病( NAFLD)患病情況。結果 顯示，對照組366例共檢齣NAFLD 67例（患病率18.3％），其中輕度51例（患病率13.9％），中度15例(4.1％)，重度1例(0.3％)。311例新診斷的2型糖尿病患者中共檢齣NAFLD 144例（患病率46.3％），其中輕度85例（患病率27.3％），中度53例(17.0％)，重度6例(1.9％)。糖尿病患者體重指數(BMI) ＜23.0kg/m2組、23.0～24.9 kg/m2組和25.0 ～ 29.9 kg/m2組中NAFLD患病率及輕中重度脂肪肝患病率明顯高于對照組（均P ＜0.01）；噹BMI≥30 kg/m2時，兩組NAFLD患病率差異無統計學意義(P＞0.05)。兩組NAFLD的患病率均隨BMI的增加而升高，噹BMI≥25.0 kg/m2時升高最為明顯，明顯高于BMI ＜25 kg/m2者(P＜0.01)。且隨著BMI的增加，2型糖尿病患者閤併代謝綜閤徵的患病率亦明顯升高。提示，2型糖尿病患者NAFLD患病率較高，伴肥胖患者更易髮生NAFLD。
대아원건강체검중심311례신진단2형당뇨병환자급종기왕무당뇨병병사차당내량정상적체검자중수궤선취적366례체검자（대조조），진행병사순문、체검급혈당、간신공능、혈지、복부채색초성등검사，분석기비주정성지방성간병( NAFLD)환병정황。결과 현시，대조조366례공검출NAFLD 67례（환병솔18.3％），기중경도51례（환병솔13.9％），중도15례(4.1％)，중도1례(0.3％)。311례신진단적2형당뇨병환자중공검출NAFLD 144례（환병솔46.3％），기중경도85례（환병솔27.3％），중도53례(17.0％)，중도6례(1.9％)。당뇨병환자체중지수(BMI) ＜23.0kg/m2조、23.0～24.9 kg/m2조화25.0 ～ 29.9 kg/m2조중NAFLD환병솔급경중중도지방간환병솔명현고우대조조（균P ＜0.01）；당BMI≥30 kg/m2시，량조NAFLD환병솔차이무통계학의의(P＞0.05)。량조NAFLD적환병솔균수BMI적증가이승고，당BMI≥25.0 kg/m2시승고최위명현，명현고우BMI ＜25 kg/m2자(P＜0.01)。차수착BMI적증가，2형당뇨병환자합병대사종합정적환병솔역명현승고。제시，2형당뇨병환자NAFLD환병솔교고，반비반환자경역발생NAFLD。
To investigate the relationship of body mass index and non-alcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus. Three hundred and eleven patients with type 2 diabetes mellitus diagnosed according WHO 1999 consensus criteria and 366 healthy subjects were enrolled in the study. Medical history was acquired and physical examination was conducted, and blood sugar, liver and kidney functions, lipid profile and abdominal ultrasonography color were examined. Sixty seven out of 366 healthy subjects were confirmed to have non-alcoholic fatty liver disease (NAFLD) ,including 51 mild case ( 13.9％ ) ,15 moderate cases(4. 1％ ) and 1 severe case(0. 3％ ) ; while in 311 diabetic patients NAFLD was detected in 144 cases, including 85 mild cases (27.3％) ,53 moderate cases( 17.3％ )and 19 severe cases( 1.9％ ). The prevalence rate of NAFLD was higher in diabetic patients than control group in BMI ＜ 23.0 kg/m2 group, 23.0 -24. 9 kg/m2 group and 25.0 -29. 9 kg/m2 group(P ＜0. 01 ) ; however, there was no difference between two groups when BMi ≥30 kg/m2 (P ＞0. 05 ). The prevalence of NAFLD increased with BMI whether in control group or in diabetic group, especially when BMI ＞ 25 kg/m2. In addition to the prevalence of NAFLD, metabolic syndrome increased with BMI in diabetic patients. These findings indicate that type 2 diabetic patients have a high prevalence of NAFLD, especially in obese patients.
