CAJ | 학술논문

目的检测参麦注射液对病毒性心肌炎患儿血清肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)及白细胞介素-6(Interleukin-6,IL-6)的影响,探讨参麦注射液治疗病毒性心肌炎的作用机制.方法采用酶联免疫吸附试验(ELISA)法检测治疗组37例和对照组35病毒性心肌炎患儿急性期和恢复期血清TNF-α,IL-6的浓度,并进行统计学比较分析.结果治疗前治疗组和对照组病毒性心肌炎患儿急性期TNF-α、IL-6浓度比较差异无统计学意义(P＞0.05),而两组治疗前后比较差异有统计学意义(P＜0.01),治疗组恢复期浓度明显低于对照组恢复期浓度,差异有统计学意义(P＜0.01).结论参麦注射液能明显降低病毒性心肌炎患儿的血清TNF-α和IL-6浓度,提示参麦注射液可能通过抑制TNF-α和IL-6合成与释放而起治疗作用.
목적 검측삼맥주사액대병독성심기염환인혈청종류배사인자-α(tumor necrosis factor-α,TNF-α)급백세포개소-6(Interleukin-6,IL-6)적영향,탐토삼맥주사액치료병독성심기염적작용궤제.방법 채용매련면역흡부시험(ELISA)법검측치료조37례화대조조35병독성심기염환인급성기화회복기혈청TNF-α,IL-6적농도,병진행통계학비교분석.결과 치료전치료조화대조조병독성심기염환인급성기TNF-α、IL-6농도비교차이무통계학의의(P＞0.05),이량조치료전후비교차이유통계학의의(P＜0.01),치료조회복기농도명현저우대조조회복기농도,차이유통계학의의(P＜0.01).결론 삼맥주사액능명현강저병독성심기염환인적혈청TNF-α화IL-6농도,제시삼맥주사액가능통과억제TNF-α화IL-6합성여석방이기치료작용.
Objective To investigate the changes of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in serum of children with viral myocarditis(VM)before and after treatment of shenmai injection,to explore the mechanism of shenmai injection in treating viral myocarditis and its clinical significance. Methods The serum levels of TNF-α and IL-6 were detected by ELISA for 37 children with VM in treatment group and 35 children in control group before and after treatment,respectively. Results The difference of serum levels of TNF-α and IL-6 in two group at the acute stage were not significant(P＞0.05), and the serum levels of TNF-α and IL-6 in two group at recovery stage were lower than those at acute stage(P＜0.01), and the serum levels of TNF-α and IL-6 were furtherly lower in treatment group than control group (P＜0.01). Conclusions Shenmai injection can significantly decrease the serum levels of TNF-α and IL-6 in children with VM, suggesting shenmai injection may play significant role in the VM pathogenesis by suppressing synthesis and releasing of TNF-α and IL-6.