CAJ | 학술논문

目的探讨血小板衍化内皮细胞生长因子(PD-ECGF)在肾细胞癌中的表达及其预后意义.方法采用免疫组化EnVision两步法检测2002年6月至2006年12月76例肾细胞癌患者肿瘤组织中PD-ECGF的表达水平,并分析其与肾细胞癌患者临床病理特征及预后的关系.结果 76例肾癌患者肿瘤组织中PD-ECGF高表达41例,低表达35例.PD-ECGF表达水平与肿瘤分期及组织学分级呈正相关.PD-ECGF高表达患者5年总生存率(60.98％)显著低于PD-ECFG低表达患者(94.29％,P=0.000).单因素分析显示肿瘤分期、淋巴结转移、远处转移、组织学分级及PD-ECGF表达水平均与肾癌患者5年生存率密切相关,Cox比例风险模型多因素分析显示肿瘤分期、组织学分级及PD-ECGF表达水平为影响肾癌患者预后的独立危险因素(OR=17.971、9.702、6.790,95％CI:3.010～107.290、1.835 ～ 51.305、1.156 ～ 39.894).结论 PD-ECGF在肾细胞癌的发生、发展中可能起重要作用,PD-ECGF高表达可能与肾细胞癌的预后有关.
목적 탐토혈소판연화내피세포생장인자(PD-ECGF)재신세포암중적표체급기예후의의.방법 채용면역조화EnVision량보법검측2002년6월지2006년12월76례신세포암환자종류조직중PD-ECGF적표체수평,병분석기여신세포암환자림상병리특정급예후적관계.결과 76례신암환자종류조직중PD-ECGF고표체41례,저표체35례.PD-ECGF표체수평여종류분기급조직학분급정정상관.PD-ECGF고표체환자5년총생존솔(60.98％)현저저우PD-ECFG저표체환자(94.29％,P=0.000).단인소분석현시종류분기、림파결전이、원처전이、조직학분급급PD-ECGF표체수평균여신암환자5년생존솔밀절상관,Cox비례풍험모형다인소분석현시종류분기、조직학분급급PD-ECGF표체수평위영향신암환자예후적독립위험인소(OR=17.971、9.702、6.790,95％CI:3.010～107.290、1.835 ～ 51.305、1.156 ～ 39.894).결론 PD-ECGF재신세포암적발생、발전중가능기중요작용,PD-ECGF고표체가능여신세포암적예후유관.
Objective To explore the expression and clinical significance of thymidine phosphorylase/platelet-derived endothelial cell growth factor (PD-ECGF) in renal cell carcinoma.Methods The expression of PD-ECGF in 76 specimens of renal cell carcinoma from June 2002 to December 2006 was examined by EnVision immunohistochemistry. The correlation of the expression of PD-ECGF with the clinicopathological characteristics and prognosis in renal cell carcinoma patients were analyzed. Results Among 76 renal cell carcinoma patients,41 patients had a high-level expression of PD-ECGF while another 35 patients a low-level expression.The expression of PD-ECGF was positively correlated with tumor stage and histological grade.The 5-year overall survival rate was significant lower in the patients with a high-level expression of PD-ECGF ( 60.98％ vs 94.29％,P =0.000 ). Univariate analysis showed that the characteristics with the prognostic significance for survival were tumor stage,lymph node metastasis,distant metastasis,histological grade and the expression of PD-ECGF. Multivariate analysis showed that tumor stage,histological grade and the expression of PD-ECGF were independent prognostic factors( OR:17.971,9.702,6.790,95％ CI:3.010-107.290,1.835 - 51.305,1.156 - 39.894).Conclusion The expression of PD-ECGF may play an important role in the development and invasion of renal cell carcinoma. An elevated level of PD-ECGF is probably correlated with the prognosis of renal cell carcinoma.