CAJ | 학술논문

目的:研究柚皮素对激光诱发大鼠脉络膜新生血管形成(CNV)、高眼压兔眼血流和缺血大鼠眼视网膜功能恢复的作用.方法:选择雄性棕色挪威大鼠,采用激光诱发Bruch膜破裂后,予10g/L(20mg/kg)柚皮素,1次/d,持续4wk;光凝后2,4wk分别做眼底荧光血管造影,评估CNV的形成.采用彩色微球技术、眼电生理技术检测兔眼血流和大鼠视网膜功能恢复.结果:与对照组比较,10g/L柚皮素能明显增加高眼压兔眼脉络膜血流(P<0.05),能明显增加缺血大鼠眼视网膜功能恢复(P<0.05),能明显减轻光凝点荧光素渗漏(75.8%～95.0%,P<0.01).结论:柚皮素能抑制激光诱发大鼠络膜新生血管形成;增加高眼压兔眼脉络膜血流;增加缺血大鼠眼视网膜功能恢复.
목적:연구유피소대격광유발대서맥락막신생혈관형성(CNV)、고안압토안혈류화결혈대서안시망막공능회복적작용.방법:선택웅성종색나위대서,채용격광유발Bruch막파렬후,여10g/L(20mg/kg)유피소,1차/d,지속4wk;광응후2,4wk분별주안저형광혈관조영,평고CNV적형성.채용채색미구기술、안전생리기술검측토안혈류화대서시망막공능회복.결과:여대조조비교,10g/L유피소능명현증가고안압토안맥락막혈류(P<0.05),능명현증가결혈대서안시망막공능회복(P<0.05),능명현감경광응점형광소삼루(75.8%～95.0%,P<0.01).결론:유피소능억제격광유발대서락막신생혈관형성;증가고안압토안맥락막혈류;증가결혈대서안시망막공능회복.
AIM: To investigate the effects of naringenin on laser-induced experimental choroidal neovascularization (CNV) in rat models,ocular blood flow in rabbit eyes and retinal function recovery after ischemic insults in rat eyes.membrane. Naringenin 10g/L(20mg/kg) was given once-daily through intraperitoneal injection for 4 weeks after laser treatment. The development of CNV was determined by fluorescein angiography(FA) performed on weeks 2 and 4. The colored microsphere technique and electroretinography method were used for the study of ocular blood flow and retinal function recovery,respectively.RESULTS: The choroidal blood flow in elevated intraocular pressure (IOP) rabbit eyes was significantly increased by 10g/L naringenin solution as compared to control group(P<0.05) . The retinal function recovery after ischemic insults in rat eyes indicated significant increase of b-wave recovery in treated group,as compared to control group(P<0.05).The intensity of fluorescein leakage from the photocoagulated lesions decreased significantly in treated group,compared to the control group(75.8%-95.0%,P<0.01). CONCLUSION: Naringenin could prevent the development of CNV on laser-induced experimental rat models,increase the choroidal blood flow in elevated IOP rabbit eyes and be beneficial on retinal function recovery in ischemic rat eyes.