CAJ | 학술논문

通过酯化反应将一定长度的烃基链引入黄酮糖苷分子中可以提高糖苷的抗氧化活性.本文以反映脂质氧化修饰程度的硫代巴比妥酸反应物质(TBARS)的含量为监测指标,用可见光分光光度计比色法对比研究了三种新合成的芦丁脂肪酸酯--芦丁硬脂酸酯、芦丁月桂酸酯、芦丁正己酸酯及芦丁对Fe~(2+)介导的卵磷脂氧化修饰的影响.结果表明三种芦丁脂肪酸酯均具有抗氧化活性,且芦丁月桂酸酯和芦丁正己酸酯的抗氧化活性均明显优于芦丁,其中芦丁正己酸酯具有最好的抗氧化活性.在芦丁分子中引入适宜长度的短烃基链可以改善其亲水亲脂平衡从而提高其抗氧化活性.
통과지화반응장일정장도적경기련인입황동당감분자중가이제고당감적항양화활성.본문이반영지질양화수식정도적류대파비타산반응물질(TBARS)적함량위감측지표,용가견광분광광도계비색법대비연구료삼충신합성적호정지방산지--호정경지산지、호정월계산지、호정정기산지급호정대Fe~(2+)개도적란린지양화수식적영향.결과표명삼충호정지방산지균구유항양화활성,차호정월계산지화호정정기산지적항양화활성균명현우우호정,기중호정정기산지구유최호적항양화활성.재호정분자중인입괄의장도적단경기련가이개선기친수친지평형종이제고기항양화활성.
Esterification of the hydroxyl groups of flavonoid glucosides by fatty acids is a possible way to improve the hy-drophilic and antioxidant properties of flavonoid glucosides. The aim of the present work was to evaluate in vitro the an-tioxidant properties of three new semisynthetic rutin derivatives, rutin-4"-O-stearate (RS), rutin-4"-O-laurate (RL) and rutin-4"-O-caproate(RC), obtained by esterification of 4-OH in the rhamnose moiety. The antioxidant activities of rutin and the three esters were assessed using the content of thiobabiturirc acid reactive substances(TBARS)as index, and the inhibitory effects on oxidative modification of lecithin induced by Fe~(2+) were compared. The results showed that three ru-tin esters could inhibit the oxidation and the role of both RL and RC were better than that of rutin; RC showed the high-est efficiency. The findings demonstrated that the esterification of 4-OH in the rhamnose moiety may improve the antioxi-dant activity of rutin.