CAJ | 학술논문

目的通过检测嗜铬蛋白A(CgA)在人乳腺组织中的表达探讨乳腺神经内分泌癌发病机制.方法免疫组化方法检测CgA在89例人乳腺组织中的表达情况.结果 CgA在乳腺正常和增生组织中均没有表达,在乳腺癌组织中有表达,发生率16.7%.其表达在癌组织与非癌组织中存在显著差异,在不同病理分级乳腺癌的表达无差异.结论乳腺神经内分泌癌发生原因可能是干细胞受微环境因素影响在细胞分化不成熟的同时出现其他方向分化或转分化;可考虑将CgA作为常规检测项目筛查此类型乳腺癌的.
목적 통과검측기락단백A(CgA)재인유선조직중적표체탐토유선신경내분비암발병궤제.방법 면역조화방법 검측CgA재89례인유선조직중적표체정황.결과 CgA재유선정상화증생조직중균몰유표체,재유선암조직중유표체,발생솔16.7%.기표체재암조직여비암조직중존재현저차이,재불동병리분급유선암적표체무차이.결론 유선신경내분비암발생원인가능시간세포수미배경인소영향재세포분화불성숙적동시출현기타방향분화혹전분화;가고필장CgA작위상규검측항목사사차류형유선암적.
Objective To explore the pathogenesis and significance of neuroendocrine breast carcinoma by detecting chromogranin A (CgA) in human mammary tissues. Method Eighty-nine cases of human mammary tissues were collected to detect CgA expression using immunohistochemistry. Result No CgA expression was detected in normal or hyperplastic tissues, but its expression was found in mammary carcinoma tissues at the rate of 16.7%. A significant difference in CgA expression was found between cancer tissues and non-cancer tissues, but not between the cancer tissues with different pathological grades. Conclusion The pathogenesis of mammary neuroendocrine carcinoma may involve the micro-environmental factors that affect the differentiation of stem ceils to give rise to immature ceils, cell differentiation in other lineages or transdifferentiation. CgA may serve as an immunological parameter for this type of breast cancer in routine screening test.