国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2008年
5期
336-339
,共4页
肝功能衰竭,急性%高迁移率族蛋白B-1%内毒素血症
肝功能衰竭,急性%高遷移率族蛋白B-1%內毒素血癥
간공능쇠갈,급성%고천이솔족단백B-1%내독소혈증
Liver failure,acute%High mobility group box 1 protein%Endotoxemia
高迁移率族蛋白B-1(HMGB1)是一种重要的晚期炎症介质,可以由坏死细胞被动释放,也可以由被激活的巨噬细胞或单核细胞主动分泌到细胞外介导炎症反应.急性肝衰竭时,内毒素血症发生率极高,HMGB1可能参与了急性肝衰竭的病理生理过程并发挥了重要作用.HMGB1将在临床上为抗急性肝衰竭提供新的治疗靶点.
高遷移率族蛋白B-1(HMGB1)是一種重要的晚期炎癥介質,可以由壞死細胞被動釋放,也可以由被激活的巨噬細胞或單覈細胞主動分泌到細胞外介導炎癥反應.急性肝衰竭時,內毒素血癥髮生率極高,HMGB1可能參與瞭急性肝衰竭的病理生理過程併髮揮瞭重要作用.HMGB1將在臨床上為抗急性肝衰竭提供新的治療靶點.
고천이솔족단백B-1(HMGB1)시일충중요적만기염증개질,가이유배사세포피동석방,야가이유피격활적거서세포혹단핵세포주동분비도세포외개도염증반응.급성간쇠갈시,내독소혈증발생솔겁고,HMGB1가능삼여료급성간쇠갈적병리생리과정병발휘료중요작용.HMGB1장재림상상위항급성간쇠갈제공신적치료파점.
High mobility group box 1 protein (HMGB1) is an important potential late mediator. It can be both passively released by necrotic cells and actively secreted by macrophages or monocytes stimulated with proinflammatory cytokines. The secretion of HMGB1 mediates inflammatory reaction. The incidence of endotoxaemia is very high in acute liver failure, HMGB1 possibly attends the pathophysiological process of acute liver failure and plays an important role. HMGB1 will expand the scope for the clinical treatment of acute liver failure patients.
