CAJ | 학술논문

目的探讨术后早期持续腹腔热灌注化疗(CHPP)对进展期胃癌的疗效.方法将70例进展期胃癌患者随机分为两组:治疗组胃癌根治术后第1～2天开始行CHPP,每日1次,共4次:对照组单纯行胃癌根治术.两组术后2-3周均予以四氢叶酸钙和氟尿嘧啶(LF方案)静脉全身化疗6个疗程.观察并比较患者术后生存和肿瘤复发情况.结果治疗组和对照组术后1年生存率分别为83.3%和79.4%,两组差异无统计学意义(P＞0.05);3年生存率分别为63.9%和39.8%.差异有统计学意义(P＜0.05).治疗组与对照组术后1年肿瘤复发率分别为8.3%和11.7%.两组差异无统计学意义(P＞0.05);3年复发率分别为19.4%和44.1%,两组差异有统计学意义(P＜0.05).结论进展期胃癌患者术后早期CHPP有利于降低复发率和提高生存率.
목적 탐토술후조기지속복강열관주화료(CHPP)대진전기위암적료효.방법 장70례진전기위암환자수궤분위량조:치료조위암근치술후제1～2천개시행CHPP,매일1차,공4차:대조조단순행위암근치술.량조술후2-3주균여이사경협산개화불뇨밀정(LF방안)정맥전신화료6개료정.관찰병비교환자술후생존화종류복발정황.결과 치료조화대조조술후1년생존솔분별위83.3%화79.4%,량조차이무통계학의의(P＞0.05);3년생존솔분별위63.9%화39.8%.차이유통계학의의(P＜0.05).치료조여대조조술후1년종류복발솔분별위8.3%화11.7%.량조차이무통계학의의(P＞0.05);3년복발솔분별위19.4%화44.1%,량조차이유통계학의의(P＜0.05).결론 진전기위암환자술후조기CHPP유리우강저복발솔화제고생존솔.
Objective To evaluate the efficacy of early continuous hyperthermic peritoneal perfusion (CHPP) on patients of advanced gastric carcinoma after surgical resection.Methods Seventy patients were divided into control and treatment group.Patients in treatment group received CHPP 1 or 2 days postoperatively. Treatment was administered daily consecutively for 4 days. Patients in control group underwent resection of gastric carcinoma without CHPP. Chemotherapy was administered of Calcium Folinate and 5-Fluorouracil (LF regimen) intravenously for 6 cycles in beth groups two or three weeks postoperatively. Survival and recurrence in beth groups were observed and compared.Results One-year survival and recurrence rates were 83.3% and 8.3% in treatment group, 79.4% and 11.7% in control group,there were no significant differences between the two groups.Three-year survival and recurrence rates were 63.9% and 19.4 in treatment group, 39.8% and 44.1% in control group,there were significant differences between the two groups.Conclusion Early administration of CHPP to patients with advanced gastric carcinoma after surgery may be advantageous for preventing peritoneal metastasis and recurrence,thus may prolong survival time.