中华风湿病学杂志
中華風濕病學雜誌
중화풍습병학잡지
CHINESE JOURNAL OF RHEUMATOLOGY
2011年
6期
400-403
,共4页
罗雄燕%武丽君%陈龙%杨明辉%刘宁涛%谢传美%唐中%史冉庚%依麦提·库尔班江%赵岩%曾小峰%袁国华
囉雄燕%武麗君%陳龍%楊明輝%劉寧濤%謝傳美%唐中%史冉庚%依麥提·庫爾班江%趙巖%曾小峰%袁國華
라웅연%무려군%진룡%양명휘%류저도%사전미%당중%사염경%의맥제·고이반강%조암%증소봉%원국화
红斑狼疮,系统性%贫血%受体,红细胞生成素
紅斑狼瘡,繫統性%貧血%受體,紅細胞生成素
홍반랑창,계통성%빈혈%수체,홍세포생성소
Lupus erythematosus,systemic%Anemia%Receptors,erythropoietin
目的 分析抗促红细胞生成素受体(EPOR)抗体在系统性红斑狼疮(SLE)中的作用,并探讨其与SLE伴贫血及病情的相关性.方法 应用酶联免疫吸附试验(ELISA)检测124例SLE患者中的抗EPOR抗体,并与7例自身免疫溶血性贫血,19例缺铁性贫血患者及45名健康人对照.同时分析SLE患者临床特点及病情活动度.所有计数资料采用x2检验或Fisher精确检验,计量资料采用t检验.结果 抗EPOR抗体在SLE组中发生率为20.2%,明显高于健康对照组的2.2%(P=0.004),而在自身免疫溶血性贫血及缺铁性贫血患者未检测到抗EPOR抗体.51例伴发贫血的SLE患者中,17例(33%)抗EPOR抗体阳性,而73例无贫血患者中仅有8例(11%)抗EPOR抗体阳性,差异有统计学意义(P=002);进一步分析发现抗EPOR抗体阳性患者其贫血程度重,而且呈现小细胞性贫血(P=0.005).对照抗EPOR抗体阳性与阴性患者的临床资料显示,皮疹(P=0.014)、补体C3下降(P=0.01)、抗dsDNA抗体阳性(P=0.000)及疾病活动积分高的SLE患者更易产生抗EPOR抗体.结论 抗EPOR抗体可能在SLE发生贫血的过程中起重要作用.ELISA测定抗EPOR抗体具有良好的稳定性和特异性,在伴发贫血的SLE患者中检测该抗体具有一定的临床价值.
目的 分析抗促紅細胞生成素受體(EPOR)抗體在繫統性紅斑狼瘡(SLE)中的作用,併探討其與SLE伴貧血及病情的相關性.方法 應用酶聯免疫吸附試驗(ELISA)檢測124例SLE患者中的抗EPOR抗體,併與7例自身免疫溶血性貧血,19例缺鐵性貧血患者及45名健康人對照.同時分析SLE患者臨床特點及病情活動度.所有計數資料採用x2檢驗或Fisher精確檢驗,計量資料採用t檢驗.結果 抗EPOR抗體在SLE組中髮生率為20.2%,明顯高于健康對照組的2.2%(P=0.004),而在自身免疫溶血性貧血及缺鐵性貧血患者未檢測到抗EPOR抗體.51例伴髮貧血的SLE患者中,17例(33%)抗EPOR抗體暘性,而73例無貧血患者中僅有8例(11%)抗EPOR抗體暘性,差異有統計學意義(P=002);進一步分析髮現抗EPOR抗體暘性患者其貧血程度重,而且呈現小細胞性貧血(P=0.005).對照抗EPOR抗體暘性與陰性患者的臨床資料顯示,皮疹(P=0.014)、補體C3下降(P=0.01)、抗dsDNA抗體暘性(P=0.000)及疾病活動積分高的SLE患者更易產生抗EPOR抗體.結論 抗EPOR抗體可能在SLE髮生貧血的過程中起重要作用.ELISA測定抗EPOR抗體具有良好的穩定性和特異性,在伴髮貧血的SLE患者中檢測該抗體具有一定的臨床價值.
목적 분석항촉홍세포생성소수체(EPOR)항체재계통성홍반랑창(SLE)중적작용,병탐토기여SLE반빈혈급병정적상관성.방법 응용매련면역흡부시험(ELISA)검측124례SLE환자중적항EPOR항체,병여7례자신면역용혈성빈혈,19례결철성빈혈환자급45명건강인대조.동시분석SLE환자림상특점급병정활동도.소유계수자료채용x2검험혹Fisher정학검험,계량자료채용t검험.결과 항EPOR항체재SLE조중발생솔위20.2%,명현고우건강대조조적2.2%(P=0.004),이재자신면역용혈성빈혈급결철성빈혈환자미검측도항EPOR항체.51례반발빈혈적SLE환자중,17례(33%)항EPOR항체양성,이73례무빈혈환자중부유8례(11%)항EPOR항체양성,차이유통계학의의(P=002);진일보분석발현항EPOR항체양성환자기빈혈정도중,이차정현소세포성빈혈(P=0.005).대조항EPOR항체양성여음성환자적림상자료현시,피진(P=0.014)、보체C3하강(P=0.01)、항dsDNA항체양성(P=0.000)급질병활동적분고적SLE환자경역산생항EPOR항체.결론 항EPOR항체가능재SLE발생빈혈적과정중기중요작용.ELISA측정항EPOR항체구유량호적은정성화특이성,재반발빈혈적SLE환자중검측해항체구유일정적림상개치.
Objective To investigate the presentationand significance of circulating autoantibodies to erythropoietin receptor (EPOR) in sera from patients with systemic lupus erythematosus (SLE). Methods One hundred and twenty-four consecutive patients with SLE, seven with autoimmune hemolytic anemia (AIHA), 19 patients with iron deficiency anemia (IDA) and 45 normal individuals were involved in this study. In all patients with SLE, the disease activity was evaluated using the European consensus Lupus Activity Measurement scale. Antibodies to EPOR were detected by enzyme-linked immunosorbent assay (ELISA). All data were tested with Chi-squared or Student's t tests by SPSS software. Results A higher frequency of antibodies to EPOR were detected in SLE patients than healthy controls (20.2% vs 2.2%, P=0.004), however, they could not be detected in AIHA and IDA patients. Moreover, anti-EPOR antibodies were detected in 17 (33.3%) of 51 SLE patients with anemia, compared with that in 8 (11.0%, P=0.002) of 73 patients without anemia. Furthermore, patients with antibodies to EPOR had more severe anemia and often presented as microcytic anemia (P =0.005) than those without anti-EPOR antibodies. Finally, anti-EPOR antibodies seemed to be more likely to occur in patients with skin rash (P=0.014), low levels of C3 component of complement (P=0.01), positive anti-dsDNA antibodies (P=0.000) and higher disease activity scores (P= 0.024). Conclusion The higher incidence of antibodies to EPOR in SLE patients with anemia suggest that anti-EPOR antibodies might play a vital role in the development of anemia in SLE patients. Thus, detecting anti-EPOR antibodies in SLE patients with anemia may be helpful.
