CAJ | 학술논문

目的探讨声触诊组织成像量化(VTQ)技术无创评价慢性肝病患者肝纤维化程度的临床价值.方法应用VTQ技术对115例拟行超声引导下肝穿刺活检慢性肝病患者和80例健康成人行肝检查,并对检查结果进行对比分析.结果慢性肝病组和健康组之间VTQ值差异有显著统计学意义(P=0.0000);慢性肝病患者不同病理分期间的VTQ值除S0与S1外,其他病理分期间差异均有统汁学意义(P=0.0212或P=0.0000);将S0-S2合并为轻度肝纤维化,S3-S4合并为中一重度肝纤维化,用ROC曲线分析阈值,当VTQ值≥1.4 m/s时,诊断中-重度肝纤维化的敏感度和特异度分别为85.4%和64.7%.结论 VTQ检查作为无创、量化的检查手段,可用来评价慢性肝病患者的肝纤维化程度.
목적 탐토성촉진조직성상양화(VTQ)기술무창평개만성간병환자간섬유화정도적림상개치.방법 응용VTQ기술대115례의행초성인도하간천자활검만성간병환자화80례건강성인행간검사,병대검사결과진행대비분석.결과 만성간병조화건강조지간VTQ치차이유현저통계학의의(P=0.0000);만성간병환자불동병리분기간적VTQ치제S0여S1외,기타병리분기간차이균유통즙학의의(P=0.0212혹P=0.0000);장S0-S2합병위경도간섬유화,S3-S4합병위중일중도간섬유화,용ROC곡선분석역치,당VTQ치≥1.4 m/s시,진단중-중도간섬유화적민감도화특이도분별위85.4%화64.7%.결론 VTQ검사작위무창、양화적검사수단,가용래평개만성간병환자적간섬유화정도.
Objective To explore the clinical value of virtual touch quantification (VTQ) technique in assessing the hepatic fibrosis. Methods A total of 115 inpatients with chronic liver disease receiving liver biopsy were enrolled in this study, all patients liver tissue was checked by VTQ technique, and the results were compared with those of the control group including 80 healthy subjects. Results VTQ value was significantly different between the two groups (P = 0.0000).The VTQ value among different degree of hepatic fibrosis but between S0 and S1 had statistical significances (P = 0.0212, P = 0.0000).ROC curve displayed that VTQ value of 1.4 m/s could be used to diagnose middle-high-grade liver fibrosis, the sensitivity and specificity were 85.4 % and 64.7%, respectively. Conclusions VTQ can be used as a noninvasive and effective means for assessing the degree of hepatic fibrosis.