CAJ | 학술논문

目的探讨血管紧张素转换酶(angiotension-convertion enzyme,ACE)基因插入/缺失(insertion/deletion,I/D)多态性与云南丽江纳西族脑血管病的相关性.方法纳入58例纳西族脑梗死患者、32例纳西族脑出血患者以及50例性别和年龄相匹配的纳西族健康对照者,采用聚合酶链反应-限制性片段长度多态性技术进行ACE基因多态性检测和双向测序.结果脑梗死组DD基因型(32.8%对16.0%,P=0.045)和D等位基因(54.3%对39.0%,P=0.025)频率均显著高于对照组,而脑出血组DD基因型和D等位基因频率与对照组无显著差异.不同脑梗死类型D等位基因携带频率不同,依次为脑栓塞＜脑血栓形成＜腔隙性梗死,腔隙性梗死患者DD基因型(40.0%对30.0%,P=0.481)和D等位基因频率(63.3%对51.2%,P-0.257)均高于脑血栓形成患者,但无显著差异.结论云南纳西族ACE基因DD型携带者具有脑梗死易感性.
목적 탐토혈관긴장소전환매(angiotension-convertion enzyme,ACE)기인삽입/결실(insertion/deletion,I/D)다태성여운남려강납서족뇌혈관병적상관성.방법 납입58례납서족뇌경사환자、32례납서족뇌출혈환자이급50례성별화년령상필배적납서족건강대조자,채용취합매련반응-한제성편단장도다태성기술진행ACE기인다태성검측화쌍향측서.결과 뇌경사조DD기인형(32.8%대16.0%,P=0.045)화D등위기인(54.3%대39.0%,P=0.025)빈솔균현저고우대조조,이뇌출혈조DD기인형화D등위기인빈솔여대조조무현저차이.불동뇌경사류형D등위기인휴대빈솔불동,의차위뇌전새＜뇌혈전형성＜강극성경사,강극성경사환자DD기인형(40.0%대30.0%,P=0.481)화D등위기인빈솔(63.3%대51.2%,P-0.257)균고우뇌혈전형성환자,단무현저차이.결론 운남납서족ACE기인DD형휴대자구유뇌경사역감성.
Objective To investigate the correlation between the angiotensin-converting enzyme(ACE)gene insertion/deletion(I/D)polymorphism and cerebrovascular diseases in Naxi population in Lijiang,Yunnan province.Methods Fifty-eight Naxi patients with cerebral infarction,32 Naxi patients with intracerebral hemorrhage,and 50 sex- and age-matched Naxi healthy controls were recruited.Polymerase chain reaction-restricted fragments length polymorphism was used to detect the ACE gene polymorphism and perform bidirectional sequencing Results The DD genotype and the D allele frequency in the cerebral infarction group were significantly higher than those in the healthy control group(32.8% vs.16.0%,P = 0.045 and 54.3% vs.39.0%,P =0.025);while there were no significant differences in the DD genotype and the D allele frequency between the intracerebral hemorrhage group and the control group.The different types of cerebral infarction carried different allele frequencies,they were in order of cerebral embolism ＜ cerebral thrombosis ＜ lacunar infarction.The DD genotype in patients with lacunar infarction(40.0% vs.30.0%,P = 0.481 )and the D allele frequencies(63.3% vs.51.2%,P =0.257)were all higher than those in patients with cerebral thrombosis,but there were no significant differences.Conclusions The ACE DD genotype carriers were susceptible to cerebral infarction in Naxi poulation in Yunan province.