中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2009年
9期
1114-1115
,共2页
戴若莲%胡波%夏远鹏%周昱男%毛玲
戴若蓮%鬍波%夏遠鵬%週昱男%毛玲
대약련%호파%하원붕%주욱남%모령
神经母细胞瘤%Shh-Gli信号途径%脱噬作用%细胞周期
神經母細胞瘤%Shh-Gli信號途徑%脫噬作用%細胞週期
신경모세포류%Shh-Gli신호도경%탈서작용%세포주기
Neuroblastoma%Shh-Gli pathway%Apoptesis%Cell cycle
Shh作用使细胞凋亡率较对照组比较下降31%,周期检测显示Shh应用后,G0/G2期细胞百分比,从对照组61.81%下降至47.29%,S期从16.55%上升至45.66%,以上差异有统计学意义(P＜0.05).结论 激活Shh-Gli信号可减少SK-N-AS细胞的凋亡,加速其进入增殖周期,促进神经母细胞瘤的存活.
Shh作用使細胞凋亡率較對照組比較下降31%,週期檢測顯示Shh應用後,G0/G2期細胞百分比,從對照組61.81%下降至47.29%,S期從16.55%上升至45.66%,以上差異有統計學意義(P＜0.05).結論 激活Shh-Gli信號可減少SK-N-AS細胞的凋亡,加速其進入增殖週期,促進神經母細胞瘤的存活.
Shh작용사세포조망솔교대조조비교하강31%,주기검측현시Shh응용후,G0/G2기세포백분비,종대조조61.81%하강지47.29%,S기종16.55%상승지45.66%,이상차이유통계학의의(P＜0.05).결론 격활Shh-Gli신호가감소SK-N-AS세포적조망,가속기진입증식주기,촉진신경모세포류적존활.
d concentration-dependent manner.Shh reduced the apeptosis by 31%,and impulsed the cell cycle from G1 to S phase.Conclusion The activation of the Shh-Gli pathway prolonged the tumor cell survival by affecting the apoptosis and cell cycle.
