中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2009年
26期
1844-1846
,共3页
何慧婵%韩兆冬%戴奇山%邹钧%张阳%张征%梁宇翔%叶永康%陈志南%钟惟德
何慧嬋%韓兆鼕%戴奇山%鄒鈞%張暘%張徵%樑宇翔%葉永康%陳誌南%鐘惟德
하혜선%한조동%대기산%추균%장양%장정%량우상%협영강%진지남%종유덕
前列腺癌%CD147%诊断%预后
前列腺癌%CD147%診斷%預後
전렬선암%CD147%진단%예후
Prostate cancer%CD147%Diagnosis%Prognosis
目的 研究细胞外基质金属蛋白酶诱导分子(CD147)在前列腺癌组织中的表达情况,探讨其临床意义.方法 应用免疫组化SP法检测101例前列腺癌组织,90例前列腺增生组织,36例正常前列腺组织和15例胚胎前列腺组织中CD147的表达情况,并对CD147表达与前列腺癌临床病理指标的关系进行统计学分析.结果 胚胎前列腺,正常前列腺,前列腺增生及前列腺癌组织CD147表达阳性率分别为:0,5.6%,23.3%,66.3%.前列腺癌与其他3组比较差异均统计学意义(均P<0.01).CD147蛋白的表达与肿瘤的TNM分期、包膜侵犯和WHO分级呈正相关.结论 CD147检测有助于提高前列腺癌的早期诊断率,希望成为反映肿瘤恶性程度及预后判断的标记物.
目的 研究細胞外基質金屬蛋白酶誘導分子(CD147)在前列腺癌組織中的錶達情況,探討其臨床意義.方法 應用免疫組化SP法檢測101例前列腺癌組織,90例前列腺增生組織,36例正常前列腺組織和15例胚胎前列腺組織中CD147的錶達情況,併對CD147錶達與前列腺癌臨床病理指標的關繫進行統計學分析.結果 胚胎前列腺,正常前列腺,前列腺增生及前列腺癌組織CD147錶達暘性率分彆為:0,5.6%,23.3%,66.3%.前列腺癌與其他3組比較差異均統計學意義(均P<0.01).CD147蛋白的錶達與腫瘤的TNM分期、包膜侵犯和WHO分級呈正相關.結論 CD147檢測有助于提高前列腺癌的早期診斷率,希望成為反映腫瘤噁性程度及預後判斷的標記物.
목적 연구세포외기질금속단백매유도분자(CD147)재전렬선암조직중적표체정황,탐토기림상의의.방법 응용면역조화SP법검측101례전렬선암조직,90례전렬선증생조직,36례정상전렬선조직화15례배태전렬선조직중CD147적표체정황,병대CD147표체여전렬선암림상병리지표적관계진행통계학분석.결과 배태전렬선,정상전렬선,전렬선증생급전렬선암조직CD147표체양성솔분별위:0,5.6%,23.3%,66.3%.전렬선암여기타3조비교차이균통계학의의(균P<0.01).CD147단백적표체여종류적TNM분기、포막침범화WHO분급정정상관.결론 CD147검측유조우제고전렬선암적조기진단솔,희망성위반영종류악성정도급예후판단적표기물.
Objective To investigate the expression of CD147 in prostate cancer and discuss its diagnostic value in prostate cancer. Methods The method of immunohistechemical SP was employed to detect the expression of CD147 in 101 cases of prostate cancer, 90 cases of benign prostatic hyperplasia, 36 cases of normal prostate and 15 cases of embryonic prostate by so as to evaluate its clinical significance in the histological classification and prognosis of prostate cancer. Results The CD147 expression was positively expressed in 67/101 (66. 3%) of prostate cancer, 21/90 (23. 3%) of benign prostatic hypertrophy, 2/36 (5. 6%) of normal prostate and 0/15 (0.0) of embryonic prostate respectively. A positive expression of CD147 was dramatically associated with TNM stage (P < 0. 001), the depth of prostatic capsule invasion (P =0. 002) and histological grade (P =0. 006). Conclusions The detection of CD147 is helpful to raise the early diagnosis rate of prostate cancer. It will become a tumor marker of reflecting the malignant degree and predicting the prognosis of prostate cancer.
