CAJ | 학술논문

目的:评估静脉注射甲基强的松龙(IVMP)对外伤性视神经病变患者的疗效.方法:回顾性分析2000-01至2007-06我院收治的16例外伤性视神经病变(TON)患者的临床资料.1g甲基强的松龙分3d静脉应用,然后口服泼尼松龙11d,并逐渐减量.记录从损伤开始到治疗开始的时间.视力变化是本研究结果的主要功能评价指标.在入院时,治疗后1,2,3d;1wk和1mo时,分别记录最佳矫正视力(BCVA).结果:共有16例患者纳入本研究,平均年龄为30岁,其中男性14例、女性2例.引起TON的主要原因有摩托车事故(占69%),打架斗殴(占19%)和体育运动(占12%).所有患者都表现有相对传入性瞳孔障碍.在损伤后4d内开始静脉注射甲基强的松龙,采用Snellen视力表检查视力,绝大部分(56%)患者视力提高超过3行或大于等于0.5(6/12).在损伤后5d以上才开始用类固醇治疗,视力则没有任何进步.结论:治疗TON,静脉注射中等到大剂量甲基强的松龙仍将起到重要作用.静脉注射甲基强的松龙治疗TON可能存在伤后4d的关键时期,超过了这个时期,该治疗可能就毫无效果.但还需要有更多的研究来为我们提供有明显统计学意义的数据.
목적:평고정맥주사갑기강적송룡(IVMP)대외상성시신경병변환자적료효.방법:회고성분석2000-01지2007-06아원수치적16예외상성시신경병변(TON)환자적림상자료.1g갑기강적송룡분3d정맥응용,연후구복발니송룡11d,병축점감량.기록종손상개시도치료개시적시간.시력변화시본연구결과적주요공능평개지표.재입원시,치료후1,2,3d;1wk화1mo시,분별기록최가교정시력(BCVA).결과:공유16례환자납입본연구,평균년령위30세,기중남성14례、녀성2례.인기TON적주요원인유마탁차사고(점69%),타가두구(점19%)화체육운동(점12%).소유환자도표현유상대전입성동공장애.재손상후4d내개시정맥주사갑기강적송룡,채용Snellen시력표검사시력,절대부분(56%)환자시력제고초과3행혹대우등우0.5(6/12).재손상후5d이상재개시용류고순치료,시력칙몰유임하진보.결론:치료TON,정맥주사중등도대제량갑기강적송룡잉장기도중요작용.정맥주사갑기강적송룡치료TON가능존재상후4d적관건시기,초과료저개시기,해치료가능취호무효과.단환수요유경다적연구래위아문제공유명현통계학의의적수거.
·AIM: To evaluate the effects of two series of enantiomers [(R, R)-XY-1 through (R, R)-XY-12 and (S,S)-XY-1 through (S, S)-XY-12] on ocular blood flow in rabbits.·METHODS; Colored microsphere technique was used for in vivo experiments to determine the ocular blood flow in various tissues of ocular hypertensive (40mmHg) rabbit eyes.·RESULTS; Of the twelve compounds of ( R, R)-XY series examined, four increased choroidal blood flow at 10g/L, 50uL instilled into eyes. All compounds of (S, S)-XY series were not effective on ocular blood flow.·CONCLUSION; Some compounds of (R, R)-XY series increased the ocular blood flow, which might be useful for the prevention and treatment of ocular blood flow related eye diseases. Among all twenty-four compounds, (R, R)-XY-1and (R, R)-XY-9 seem to be the most potent ones.KEYWORDS; ocular blood flow; ischemia; enantiomer