国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2012年
1期
5-8
,共4页
王丽莉%诸葛欣%陈翊玲%张蕴
王麗莉%諸葛訢%陳翊玲%張蘊
왕려리%제갈흔%진익령%장온
2型糖尿病%血管新生%CXCL16%踝臂指数
2型糖尿病%血管新生%CXCL16%踝臂指數
2형당뇨병%혈관신생%CXCL16%과비지수
Type 2 diabetes mellitus%Angiogenesis%CXCL16%Ankle brachial index
目的 观察2型糖尿病(T2DM)下肢血管病变患者血管新生相关因子的变化,探讨血管新生在糖尿病下肢血管病变发展中的作用.方法 测定31例T2DM无下肢血管病变患者(T2DM 组)、49例T2DM下肢血管病变患者(下肢血管病变组)及40例正常对照者(对照组)血清CXCL16、碱性成纤维细胞生长因子(bFGF)、血小板源性内皮细胞生长因子(PD-ECGF)水平和外周血内皮祖细胞(EPCs)数量.应用多普勒超声测定踝臂指数(ABI),左、右足背动脉及左、右腘动脉内径,血流流速.结果 T2DM组和对照组相比,血清bFGF、PD-ECGF水平升高(P均＜0.01),外周血EPCs数量下降(P ＜0.001).下肢血管病变组与T2DM组和对照组相比,血清CXCL16、bFGF、PD-ECGF水平升高(P均＜0.001),外周血EPCs数量下降(P＜0.01).下肢血管病变组和T2DM组、对照组相比,ABI下降(P＜0.01),左、右足背动脉,左、右胭动脉内径减小(P＜0.01或P＜0.05),下肢血管病变组和对照组相比,左、右足背动脉,左、右胭动脉血流流速减低(P＜0.05).结论 T2DM下肢血管病变患者存在血管新生障碍,血管新生相关因子的升高和EPCs数量下降在糖尿病下肢血管病变发生中可能起重要作用.
目的 觀察2型糖尿病(T2DM)下肢血管病變患者血管新生相關因子的變化,探討血管新生在糖尿病下肢血管病變髮展中的作用.方法 測定31例T2DM無下肢血管病變患者(T2DM 組)、49例T2DM下肢血管病變患者(下肢血管病變組)及40例正常對照者(對照組)血清CXCL16、堿性成纖維細胞生長因子(bFGF)、血小闆源性內皮細胞生長因子(PD-ECGF)水平和外週血內皮祖細胞(EPCs)數量.應用多普勒超聲測定踝臂指數(ABI),左、右足揹動脈及左、右腘動脈內徑,血流流速.結果 T2DM組和對照組相比,血清bFGF、PD-ECGF水平升高(P均＜0.01),外週血EPCs數量下降(P ＜0.001).下肢血管病變組與T2DM組和對照組相比,血清CXCL16、bFGF、PD-ECGF水平升高(P均＜0.001),外週血EPCs數量下降(P＜0.01).下肢血管病變組和T2DM組、對照組相比,ABI下降(P＜0.01),左、右足揹動脈,左、右胭動脈內徑減小(P＜0.01或P＜0.05),下肢血管病變組和對照組相比,左、右足揹動脈,左、右胭動脈血流流速減低(P＜0.05).結論 T2DM下肢血管病變患者存在血管新生障礙,血管新生相關因子的升高和EPCs數量下降在糖尿病下肢血管病變髮生中可能起重要作用.
목적 관찰2형당뇨병(T2DM)하지혈관병변환자혈관신생상관인자적변화,탐토혈관신생재당뇨병하지혈관병변발전중적작용.방법 측정31례T2DM무하지혈관병변환자(T2DM 조)、49례T2DM하지혈관병변환자(하지혈관병변조)급40례정상대조자(대조조)혈청CXCL16、감성성섬유세포생장인자(bFGF)、혈소판원성내피세포생장인자(PD-ECGF)수평화외주혈내피조세포(EPCs)수량.응용다보륵초성측정과비지수(ABI),좌、우족배동맥급좌、우객동맥내경,혈류류속.결과 T2DM조화대조조상비,혈청bFGF、PD-ECGF수평승고(P균＜0.01),외주혈EPCs수량하강(P ＜0.001).하지혈관병변조여T2DM조화대조조상비,혈청CXCL16、bFGF、PD-ECGF수평승고(P균＜0.001),외주혈EPCs수량하강(P＜0.01).하지혈관병변조화T2DM조、대조조상비,ABI하강(P＜0.01),좌、우족배동맥,좌、우연동맥내경감소(P＜0.01혹P＜0.05),하지혈관병변조화대조조상비,좌、우족배동맥,좌、우연동맥혈류류속감저(P＜0.05).결론 T2DM하지혈관병변환자존재혈관신생장애,혈관신생상관인자적승고화EPCs수량하강재당뇨병하지혈관병변발생중가능기중요작용.
Objective To inveshgate the changes of angiogenesis-related factors,and evaluate the effects of angiogenesis on lower extremity angiopathy in patients with type 2 diabetes mellitus (T2DM).Methods Serum levels of CXCL16,basic fibroblast growth factor (bFGF),platelet-derived endothelial cell growth factor (PD-ECGF) and the number of endothelial progenitor cells (EPCs) were examined in 31 T2DM patients without lower extremity angiopathy( T2DM group),49 T2DM patients with lower extremity angiopathy( lower extremity angiopathy group),and 40 healthy controls (control group).Ankle brachial index (ABI),the inside diameter and blood velocity of arteria dorsalis pedis and arteria poplitea were measured with color Doppler ultrasonography.Results Serum levels of bFGF and PD-ECGF were significantly increased( P ＜ 0.05 ) and the number of EPCs were significantly decreased( P ＜ 0.001 ) in T2DM group compared with those in control group.The serum levels of CXCL16,bFGF and PD-ECGF were significantly increased ( P ＜ 0.05 ) and the number of EPCs were significantly decreased( P ＜ 0.01 ) in lower extremity angiopathy group compared with those in T2DM group and in control group.ABI,the inside diameter of arteria dorsalis pedis and arteria poplitea were significantly decreased (P ＜ 0.01 or P ＜ 0.05 ) in lower extremity angiopathy group compared with those in T2DM group and in control group.The blood velocity of arteria dorsalis pedis and arteria poplitea were significantly decreased(P ＜ 0.05) in lower extremity angiopathy group compared with those in control group.Conclusions There was angiogenic impairment in patients with T2DM.Increased angiogenesis-related factors and decreased number of EPCs may play important roles in lower extremity angiopathy of T2DM.
