中国临床实用医学
中國臨床實用醫學
중국림상실용의학
CHINA CLINICAL PRACTICAL MEDICINE
2008年
4期
19-20
,共2页
终末期肾病%抑郁%焦虑%帕罗西汀
終末期腎病%抑鬱%焦慮%帕囉西汀
종말기신병%억욱%초필%파라서정
End-stage-renal disease (ERSD):Depression%Anxietv%Paroxetine
目的 评价帕罗西汀治疗终末期肾病(ERSD)患者的焦虑与抑郁症状的疗效.方法 对74名伴发抑郁焦虑障碍终末期肾病患者,进行为期4周的随机对照研究,实验组、对照组各37例,以汉密顿焦虑量表(HAMA)和汉密顿抑郁量表(HAMD)评定疗效.结果 帕罗西汀组焦虑与抑郁症状的减轻明显优于对照组(P<0.05～0.01).结论 帕罗西汀能有效减轻终末期肾病患者的焦虑、抑郁症状,且不良反应小,提高对透析治疗的依从性.
目的 評價帕囉西汀治療終末期腎病(ERSD)患者的焦慮與抑鬱癥狀的療效.方法 對74名伴髮抑鬱焦慮障礙終末期腎病患者,進行為期4週的隨機對照研究,實驗組、對照組各37例,以漢密頓焦慮量錶(HAMA)和漢密頓抑鬱量錶(HAMD)評定療效.結果 帕囉西汀組焦慮與抑鬱癥狀的減輕明顯優于對照組(P<0.05～0.01).結論 帕囉西汀能有效減輕終末期腎病患者的焦慮、抑鬱癥狀,且不良反應小,提高對透析治療的依從性.
목적 평개파라서정치료종말기신병(ERSD)환자적초필여억욱증상적료효.방법 대74명반발억욱초필장애종말기신병환자,진행위기4주적수궤대조연구,실험조、대조조각37례,이한밀돈초필량표(HAMA)화한밀돈억욱량표(HAMD)평정료효.결과 파라서정조초필여억욱증상적감경명현우우대조조(P<0.05～0.01).결론 파라서정능유효감경종말기신병환자적초필、억욱증상,차불량반응소,제고대투석치료적의종성.
Objective To evaluate the therapeutic effects of paroxetine for anxiety and depression of end-stage-renal disease(ERSD). Methods 74 patients of ERSD with depression and anxiety were divided into 2 groups and entered an 4-week randomized placebo-controlled trial, 37 patients were treated by paroxctine,Hamilton Rating Scale for Depression(HAMD) and Hamilton Rating Scale for Anxiety (HAMA) were used to evaluate the therapeutic effects of paroxetine,and controlled with 37 trial. Results Compared with the scores before therapy, the scores evaluated by HAMD and HAMA of paroxetine groups after therapy decreased signifi-cantly(P<0.05～0.01). Conclusion Paroxetine effectively reduces the severity of depression and anxiety in ERSD patients, this treatment also can produced a trend better
