中华核医学杂志
中華覈醫學雜誌
중화핵의학잡지
CHINESE JOURNAL OF NUCLEAR MEDICINE
2008年
5期
295-298
,共4页
理东丽%李洪生%王全师%王巧愚%吴湖炳
理東麗%李洪生%王全師%王巧愚%吳湖炳
리동려%리홍생%왕전사%왕교우%오호병
黑色素瘤%体层摄影术,发射型计算机%体层摄影术,X线计算机%脱氧葡萄糖
黑色素瘤%體層攝影術,髮射型計算機%體層攝影術,X線計算機%脫氧葡萄糖
흑색소류%체층섭영술,발사형계산궤%체층섭영술,X선계산궤%탈양포도당
Melanoma%Tomography,emission-computed%Tomography X-ray computed%Deoxyglucose
目的 探讨18F-脱氧葡萄糖(FDG)PET/CT显像在黑色素瘤诊断、临床分期及监测治疗后肿瘤复发与转移灶中的应用价值.方法 黑色素瘤患者61例,均进行18F-FDG PET/CT全身显像.所有PET、CT及PET/CT融合图像均通过融合软件进行帧对帧对比分析.肿瘤病灶根据病理学检查、多种影像学检查及临床随访结果诊断.结果 18F-FDG PET/CT显像对黑色素瘤病灶检出的灵敏度、特异性和准确性分别为90.9%(40/44)、88.2%(15/17)和90.2%(55/61).其中12例治疗前患者中,18F-FDG PET/CT显像诊断的灵敏度为83.3%(10/12).在黑色素瘤病灶局部切除、尚未进行其他治疗的9例患者中,5例残余病灶18F-FDG PET/CT显像检出3例;4例远处转移灶患者全被检出,提高了临床分期,改变了治疗方案.首先发现转移性黑色素瘤病灶并且手术切除后,寻找原发灶的7例患者中,18F-FDG PET/CT检出原发灶2例,4例其他转移灶全被检出.黑色素瘤患者根治术后监测肿瘤复发或转移患者33例,18F-FDG PET/CT显像灵敏度、特异性和准确性分别为100.0%(19/19)、85.7%(12/14)和93.9%(31/33).与同期临床其他影像学检查比较,18F-FDG PET/CT显像发现更多,33例患者中,16例(48.5%)病灶提高临床分期;7例(21.2%)排除可疑病灶,降低临床分期;10例(30.3%)检出病灶与临床一致.结论 18F-FDG PET/CT显像对于黑色素瘤的诊断,残余病灶、复发病灶及转移灶的检出,临床分期的明确具有重要价值.
目的 探討18F-脫氧葡萄糖(FDG)PET/CT顯像在黑色素瘤診斷、臨床分期及鑑測治療後腫瘤複髮與轉移竈中的應用價值.方法 黑色素瘤患者61例,均進行18F-FDG PET/CT全身顯像.所有PET、CT及PET/CT融閤圖像均通過融閤軟件進行幀對幀對比分析.腫瘤病竈根據病理學檢查、多種影像學檢查及臨床隨訪結果診斷.結果 18F-FDG PET/CT顯像對黑色素瘤病竈檢齣的靈敏度、特異性和準確性分彆為90.9%(40/44)、88.2%(15/17)和90.2%(55/61).其中12例治療前患者中,18F-FDG PET/CT顯像診斷的靈敏度為83.3%(10/12).在黑色素瘤病竈跼部切除、尚未進行其他治療的9例患者中,5例殘餘病竈18F-FDG PET/CT顯像檢齣3例;4例遠處轉移竈患者全被檢齣,提高瞭臨床分期,改變瞭治療方案.首先髮現轉移性黑色素瘤病竈併且手術切除後,尋找原髮竈的7例患者中,18F-FDG PET/CT檢齣原髮竈2例,4例其他轉移竈全被檢齣.黑色素瘤患者根治術後鑑測腫瘤複髮或轉移患者33例,18F-FDG PET/CT顯像靈敏度、特異性和準確性分彆為100.0%(19/19)、85.7%(12/14)和93.9%(31/33).與同期臨床其他影像學檢查比較,18F-FDG PET/CT顯像髮現更多,33例患者中,16例(48.5%)病竈提高臨床分期;7例(21.2%)排除可疑病竈,降低臨床分期;10例(30.3%)檢齣病竈與臨床一緻.結論 18F-FDG PET/CT顯像對于黑色素瘤的診斷,殘餘病竈、複髮病竈及轉移竈的檢齣,臨床分期的明確具有重要價值.
목적 탐토18F-탈양포도당(FDG)PET/CT현상재흑색소류진단、림상분기급감측치료후종류복발여전이조중적응용개치.방법 흑색소류환자61례,균진행18F-FDG PET/CT전신현상.소유PET、CT급PET/CT융합도상균통과융합연건진행정대정대비분석.종류병조근거병이학검사、다충영상학검사급림상수방결과진단.결과 18F-FDG PET/CT현상대흑색소류병조검출적령민도、특이성화준학성분별위90.9%(40/44)、88.2%(15/17)화90.2%(55/61).기중12례치료전환자중,18F-FDG PET/CT현상진단적령민도위83.3%(10/12).재흑색소류병조국부절제、상미진행기타치료적9례환자중,5례잔여병조18F-FDG PET/CT현상검출3례;4례원처전이조환자전피검출,제고료림상분기,개변료치료방안.수선발현전이성흑색소류병조병차수술절제후,심조원발조적7례환자중,18F-FDG PET/CT검출원발조2례,4례기타전이조전피검출.흑색소류환자근치술후감측종류복발혹전이환자33례,18F-FDG PET/CT현상령민도、특이성화준학성분별위100.0%(19/19)、85.7%(12/14)화93.9%(31/33).여동기림상기타영상학검사비교,18F-FDG PET/CT현상발현경다,33례환자중,16례(48.5%)병조제고림상분기;7례(21.2%)배제가의병조,강저림상분기;10례(30.3%)검출병조여림상일치.결론 18F-FDG PET/CT현상대우흑색소류적진단,잔여병조、복발병조급전이조적검출,림상분기적명학구유중요개치.
Objective The aim of this study was to evaluate the clinical role of 18s F-fluoredeoxyglucase (FDG) PET/CT in detection of malignant melanoma. Methods The whole body 18F-FDG PET/CT scans were performed on 61 patients with malignant melanoma. All PET and CT images of one patient were fused by the specific software on workstation. PET images, CT images and PET/CT fused images were analyzed by flame to frame. All patients were followed up for at least six months or last to the patient death.The final diagnosis was obtained by pathologic finding from surgery or biopsy, and (or) multi-modalities of imaging and clinical follow-up. Results The overall sensitivity, specificity and accuracy of 18F-FDG PET/ CT for detecting primary malignant melanoma was 90.9% (40/44), 88.2% (15/17) and 90.2% (55/61),respectively. In 9 patients post local surgery and proven histologically malignant melanoma, 18F-FDG PET/CT detected the residual and metastatic tumor in 3/5 and 4/4 cases, respectively. In 7 patients with metastastic melanoma, 18F-FDG PET/CT found primary tumors in 2 cases and metastatic loci in 4 cases. In 33 patients after the radical operation, the sensitivity, specificity and accuracy of 18F-FDG PET/CT for detecting recurrence or metastasis was 100.0%(19/19), 85.7% (12/14) and 93.9% (31/33), respectively.Of these 33 patients, 16 (48.5%) were up-staged and 7 (21.2%) were down-staged by 18F-FDG PET/CT. Conclusion 18F-FDG PET/CT is a valuable imaging tool to detect the residual, recurrent and metastatic tumor in patients with malignant melanoma.
