CAJ | 학술논문

新近研究发现,结肠癌转移相关基因1( MACC1)在人类多种肿瘤中存在异常高表达,作为肝细胞生长因子-酪氮酸激酶受体(HGF-MET)信号通路的关键调控者,可以明显上调MET蛋白的表达,促进肿瘤细胞的运动、侵袭和转移.进一步的研究将有助于阐明肿瘤转移的机制,同时也为肿瘤转移靶向治疗提供了新思路.
신근연구발현,결장암전이상관기인1( MACC1)재인류다충종류중존재이상고표체,작위간세포생장인자-락담산격매수체(HGF-MET)신호통로적관건조공자,가이명현상조MET단백적표체,촉진종류세포적운동、침습화전이.진일보적연구장유조우천명종류전이적궤제,동시야위종류전이파향치료제공료신사로.
Recent findings indicate that metastasis-associated gene in colon cancer 1 ( MACC1 ) has an abnormal high expression in most malignant tumors.As a key regulator of HGF-MET signal pathway,MACC1 could obviously up-regulate the expression of MET and promote cancer cell's movement,invasion and metastasis.Further studies will shed light on elucidating the mechanisms of metastasis and may provide a new method for targeted therapy.