中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2009年
11期
918-920
,共3页
降血脂药%糖尿病%2型%高脂血症
降血脂藥%糖尿病%2型%高脂血癥
강혈지약%당뇨병%2형%고지혈증
Antilipemic agents%Diabetes mellitus%type 2%Hyperlipidaemias
目的 观察阿托伐他汀对老年2型糖尿病合并高脂血症患者降脂的疗效. 方法 研究对象每晚睡前服用阿托伐他汀片10 mg,疗程为12个月.治疗前及治疗后3、6、9、12个月分别测定血总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、谷丙转氨酶、谷草转氨酶、血糖、肌酐及颈总动脉、髂总动脉、股动脉的内膜中层厚度(IMT).结果阿托伐他汀治疗1年后,患者TC和LDL-C显著降低[(5.11±0.94)mmol/L至(4.46±0.98)mmol/L和(3.01±0.78)mmol/L至(2.55±0.83)mmol/L,均P<0.01],不同检测时间点LDL-C均达到治疗标准(<2.59 mmol/L),但TC只有在9个月时降至标准以下(<4.04 mmol/L).颈总动脉、髂总动脉和股动脉的IMT均呈减少的趋势,但差异无统计学意义,谷丙转氨酶、谷草转氨酶和肌酐无明显变化. 结论 阿托伐他汀对老年2型糖尿病合并高脂血症患者有明显降脂效果,不良反应小,并且具有保护血管内膜的作用.
目的 觀察阿託伐他汀對老年2型糖尿病閤併高脂血癥患者降脂的療效. 方法 研究對象每晚睡前服用阿託伐他汀片10 mg,療程為12箇月.治療前及治療後3、6、9、12箇月分彆測定血總膽固醇(TC)、三酰甘油(TG)、高密度脂蛋白膽固醇(HDL-C)、低密度脂蛋白膽固醇(LDL-C)、穀丙轉氨酶、穀草轉氨酶、血糖、肌酐及頸總動脈、髂總動脈、股動脈的內膜中層厚度(IMT).結果阿託伐他汀治療1年後,患者TC和LDL-C顯著降低[(5.11±0.94)mmol/L至(4.46±0.98)mmol/L和(3.01±0.78)mmol/L至(2.55±0.83)mmol/L,均P<0.01],不同檢測時間點LDL-C均達到治療標準(<2.59 mmol/L),但TC隻有在9箇月時降至標準以下(<4.04 mmol/L).頸總動脈、髂總動脈和股動脈的IMT均呈減少的趨勢,但差異無統計學意義,穀丙轉氨酶、穀草轉氨酶和肌酐無明顯變化. 結論 阿託伐他汀對老年2型糖尿病閤併高脂血癥患者有明顯降脂效果,不良反應小,併且具有保護血管內膜的作用.
목적 관찰아탁벌타정대노년2형당뇨병합병고지혈증환자강지적료효. 방법 연구대상매만수전복용아탁벌타정편10 mg,료정위12개월.치료전급치료후3、6、9、12개월분별측정혈총담고순(TC)、삼선감유(TG)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)、곡병전안매、곡초전안매、혈당、기항급경총동맥、가총동맥、고동맥적내막중층후도(IMT).결과아탁벌타정치료1년후,환자TC화LDL-C현저강저[(5.11±0.94)mmol/L지(4.46±0.98)mmol/L화(3.01±0.78)mmol/L지(2.55±0.83)mmol/L,균P<0.01],불동검측시간점LDL-C균체도치료표준(<2.59 mmol/L),단TC지유재9개월시강지표준이하(<4.04 mmol/L).경총동맥、가총동맥화고동맥적IMT균정감소적추세,단차이무통계학의의,곡병전안매、곡초전안매화기항무명현변화. 결론 아탁벌타정대노년2형당뇨병합병고지혈증환자유명현강지효과,불량반응소,병차구유보호혈관내막적작용.
Objective To observe the effect of atorvastatin on lowering blood lipid in patients with type 2 diabetic mellitus plus hyperlipidemia. Methods All patients took 10 mg atorvastatin every night for 12 months. The levels of total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), serum alanine aminotransferase (ALT), aspartate aminotransferase fAST), fasting blood glucose (FBG), creatinine (Cr), intima media thickness (IMT) of carotid artery (CA), common lilac artery (CIA) and femoral artery (CFA) were examined before and 3, 6, 9, 12 months after the treatment. Results TC [(5.11±0.94) vs. (4.46±0.98) mmol/L, P<0.01] and LDL-C [(3.01±0.78) vs. (2.55± 0.83) mmol/L, P<0. 01] were significantly decreased one year after the treatment. At different detection time points, the levels of LDL-C all reached the therapy standard (<2.59 mmol/L). But TC reached the therapy standard (<4.04 mmol/L) only at nine months after the treatment. IMT of CA, CIA and CFA were at the decreased tendency (P>0. 05). No significant changes were observed in ALT, AST and Cr. Conclusions Atorvastatin may significantly decreased the level of blood lipid with little adverse effect in elderly patients with type 2 diabetic mellitus plus hyperlipidemia, and it also has the effect of protecting the vascular intima.
