目的 调查我国长寿地区百岁老人慢性病及有关健康指标的情况,并与其他各年龄组进行比较分析.方法 以我国7个长寿之乡参加2008-2009年中国老年人口健康影响因素跟踪调查(CLHLS)项目的居民作为目标对象,最终有2029名40岁以上人群参加调查,其中40～岁组469名、60～岁组436名、80～岁组346名、90～岁组380名、100～岁组398名.采用自行设计的调查表收集社会人口学特征等信息,由临床医生采用统一的检查工具对研究对象进行体检,采集静脉血和尿液,用仪器分析法、原子吸收法等进行血常规、尿常规、血浆宏量和微量元素、血浆生化等检测.采用卡方检验等对数据进行分析.结果 40～、60～、80～、90～、100～岁组男性体质指数(BMI)分别为(23.2±4.6)、(22.1±3.7)、(20.2±3.4)、(20.2±3.9)、(19.1±5.0)kg/m~2(F=22.78,P<0.01),女性分别为(23.3±4.0)、(21.6±3.5)、(19.7±3.9)、(19.0±4.8)、(18.4±3.8)kg/m~2(F=51.84,P<0.01);男性高血压患病率分别为38.3%(80/209)、60.8%(166/273)、63.5%(106/167)、61.8%(68/110)、54.8%(34/62)(χ~2=34.26,P<0.01),女性为32.3%(84/260)、60.1%(98/163)、69.8%(125/179)、61.5%(166/270)、58.9%(198/336)(χ~2=78.45,P<0.01);男性糖尿病患病率为10.5%(22/209)、12.5%(34/273)、9.0%(15/167)、18.2%(20/110)、12.9%(8/62)(χ~2=5.92,P=0.20),女性为4.2%(11/x,o)、15.3%(25/163)、10.1%(18/179)、12.2%(33/270)、7.4%(25/336)(χ~2=19.25,P<0.01).40～、90～、100～岁组中,男性超氧化物歧化酶(SOD)活性为(29.03±5.79)、(30.93±5.39)、(31.63±5.92)U/ml(F=4.40,P<0.05),女性为(28.27±6.25)、(30.86±5.72)、(31.55±5.25)U/ml(F=13.13,P<0.05);男性血浆钙浓度为(3.63±1.08)、(3.09±0.91)、(3.34±1.07)mmol/L(F=5.71,P<0.01),女性为(3.84±1.02)、(3.19±1.16)、(3.38±1.16)mmol/L(F=11.61,P<0.01);男性血浆硒浓度为(1.44±0.86)、(1.28±0.60)、(1.75±0.57)μmol/L(F=3.79,P<0.05),女性为(1.44±0.80)、(1.48±0.81)、(1.78±0.80)μmol/L(F=8.69,P<0.01);男性血浆铁浓度为(63.25±49.05)、(71.86±54.16)、(138.36±77.60)μmol/L(F=22.78,P<0.01),女性为(64.86±57.72)、(74.56±56.93)、(106.56±74.08)μmol/L(F=17.88,P<0.01);男性血浆铜浓度为(23.49±12.85)、(17.96±7.57)、(22.33±6.89)μmol/L(F=5.18,P<0.01),女性为(21.52±10.63)、(19.60±9.57)、(22.99±8.71)μmol/L(F=5.68,P<0.01);男性血浆超敏C反应蛋白(hsCRP)阳性率分别为5.5%(8/146)、24.0%(18/75)、31.3%(10/32)(χ~2=22.62,P<0.01),女性为9.8%(12/122)、19.6%(40/204)、25.1%(49/195)(χ~2=11.24,P<0.01).结论 100～岁组较其他年龄组具有相对较低的慢性病发生风险和较高的抗氧化机能,较90～岁组血浆中有较高含量的营养元素,但体内炎症较为普遍.
目的 調查我國長壽地區百歲老人慢性病及有關健康指標的情況,併與其他各年齡組進行比較分析.方法 以我國7箇長壽之鄉參加2008-2009年中國老年人口健康影響因素跟蹤調查(CLHLS)項目的居民作為目標對象,最終有2029名40歲以上人群參加調查,其中40～歲組469名、60～歲組436名、80～歲組346名、90～歲組380名、100～歲組398名.採用自行設計的調查錶收集社會人口學特徵等信息,由臨床醫生採用統一的檢查工具對研究對象進行體檢,採集靜脈血和尿液,用儀器分析法、原子吸收法等進行血常規、尿常規、血漿宏量和微量元素、血漿生化等檢測.採用卡方檢驗等對數據進行分析.結果 40～、60～、80～、90～、100～歲組男性體質指數(BMI)分彆為(23.2±4.6)、(22.1±3.7)、(20.2±3.4)、(20.2±3.9)、(19.1±5.0)kg/m~2(F=22.78,P<0.01),女性分彆為(23.3±4.0)、(21.6±3.5)、(19.7±3.9)、(19.0±4.8)、(18.4±3.8)kg/m~2(F=51.84,P<0.01);男性高血壓患病率分彆為38.3%(80/209)、60.8%(166/273)、63.5%(106/167)、61.8%(68/110)、54.8%(34/62)(χ~2=34.26,P<0.01),女性為32.3%(84/260)、60.1%(98/163)、69.8%(125/179)、61.5%(166/270)、58.9%(198/336)(χ~2=78.45,P<0.01);男性糖尿病患病率為10.5%(22/209)、12.5%(34/273)、9.0%(15/167)、18.2%(20/110)、12.9%(8/62)(χ~2=5.92,P=0.20),女性為4.2%(11/x,o)、15.3%(25/163)、10.1%(18/179)、12.2%(33/270)、7.4%(25/336)(χ~2=19.25,P<0.01).40～、90～、100～歲組中,男性超氧化物歧化酶(SOD)活性為(29.03±5.79)、(30.93±5.39)、(31.63±5.92)U/ml(F=4.40,P<0.05),女性為(28.27±6.25)、(30.86±5.72)、(31.55±5.25)U/ml(F=13.13,P<0.05);男性血漿鈣濃度為(3.63±1.08)、(3.09±0.91)、(3.34±1.07)mmol/L(F=5.71,P<0.01),女性為(3.84±1.02)、(3.19±1.16)、(3.38±1.16)mmol/L(F=11.61,P<0.01);男性血漿硒濃度為(1.44±0.86)、(1.28±0.60)、(1.75±0.57)μmol/L(F=3.79,P<0.05),女性為(1.44±0.80)、(1.48±0.81)、(1.78±0.80)μmol/L(F=8.69,P<0.01);男性血漿鐵濃度為(63.25±49.05)、(71.86±54.16)、(138.36±77.60)μmol/L(F=22.78,P<0.01),女性為(64.86±57.72)、(74.56±56.93)、(106.56±74.08)μmol/L(F=17.88,P<0.01);男性血漿銅濃度為(23.49±12.85)、(17.96±7.57)、(22.33±6.89)μmol/L(F=5.18,P<0.01),女性為(21.52±10.63)、(19.60±9.57)、(22.99±8.71)μmol/L(F=5.68,P<0.01);男性血漿超敏C反應蛋白(hsCRP)暘性率分彆為5.5%(8/146)、24.0%(18/75)、31.3%(10/32)(χ~2=22.62,P<0.01),女性為9.8%(12/122)、19.6%(40/204)、25.1%(49/195)(χ~2=11.24,P<0.01).結論 100～歲組較其他年齡組具有相對較低的慢性病髮生風險和較高的抗氧化機能,較90～歲組血漿中有較高含量的營養元素,但體內炎癥較為普遍.
목적 조사아국장수지구백세노인만성병급유관건강지표적정황,병여기타각년령조진행비교분석.방법 이아국7개장수지향삼가2008-2009년중국노년인구건강영향인소근종조사(CLHLS)항목적거민작위목표대상,최종유2029명40세이상인군삼가조사,기중40～세조469명、60～세조436명、80～세조346명、90～세조380명、100～세조398명.채용자행설계적조사표수집사회인구학특정등신식,유림상의생채용통일적검사공구대연구대상진행체검,채집정맥혈화뇨액,용의기분석법、원자흡수법등진행혈상규、뇨상규、혈장굉량화미량원소、혈장생화등검측.채용잡방검험등대수거진행분석.결과 40～、60～、80～、90～、100～세조남성체질지수(BMI)분별위(23.2±4.6)、(22.1±3.7)、(20.2±3.4)、(20.2±3.9)、(19.1±5.0)kg/m~2(F=22.78,P<0.01),녀성분별위(23.3±4.0)、(21.6±3.5)、(19.7±3.9)、(19.0±4.8)、(18.4±3.8)kg/m~2(F=51.84,P<0.01);남성고혈압환병솔분별위38.3%(80/209)、60.8%(166/273)、63.5%(106/167)、61.8%(68/110)、54.8%(34/62)(χ~2=34.26,P<0.01),녀성위32.3%(84/260)、60.1%(98/163)、69.8%(125/179)、61.5%(166/270)、58.9%(198/336)(χ~2=78.45,P<0.01);남성당뇨병환병솔위10.5%(22/209)、12.5%(34/273)、9.0%(15/167)、18.2%(20/110)、12.9%(8/62)(χ~2=5.92,P=0.20),녀성위4.2%(11/x,o)、15.3%(25/163)、10.1%(18/179)、12.2%(33/270)、7.4%(25/336)(χ~2=19.25,P<0.01).40～、90～、100～세조중,남성초양화물기화매(SOD)활성위(29.03±5.79)、(30.93±5.39)、(31.63±5.92)U/ml(F=4.40,P<0.05),녀성위(28.27±6.25)、(30.86±5.72)、(31.55±5.25)U/ml(F=13.13,P<0.05);남성혈장개농도위(3.63±1.08)、(3.09±0.91)、(3.34±1.07)mmol/L(F=5.71,P<0.01),녀성위(3.84±1.02)、(3.19±1.16)、(3.38±1.16)mmol/L(F=11.61,P<0.01);남성혈장서농도위(1.44±0.86)、(1.28±0.60)、(1.75±0.57)μmol/L(F=3.79,P<0.05),녀성위(1.44±0.80)、(1.48±0.81)、(1.78±0.80)μmol/L(F=8.69,P<0.01);남성혈장철농도위(63.25±49.05)、(71.86±54.16)、(138.36±77.60)μmol/L(F=22.78,P<0.01),녀성위(64.86±57.72)、(74.56±56.93)、(106.56±74.08)μmol/L(F=17.88,P<0.01);남성혈장동농도위(23.49±12.85)、(17.96±7.57)、(22.33±6.89)μmol/L(F=5.18,P<0.01),녀성위(21.52±10.63)、(19.60±9.57)、(22.99±8.71)μmol/L(F=5.68,P<0.01);남성혈장초민C반응단백(hsCRP)양성솔분별위5.5%(8/146)、24.0%(18/75)、31.3%(10/32)(χ~2=22.62,P<0.01),녀성위9.8%(12/122)、19.6%(40/204)、25.1%(49/195)(χ~2=11.24,P<0.01).결론 100～세조교기타년령조구유상대교저적만성병발생풍험화교고적항양화궤능,교90～세조혈장중유교고함량적영양원소,단체내염증교위보편.
Objective To describe chronic diseases and other related health indicators of centenarians,compare these health indicators with other age groups in longevity areas in China. Methods Residents who participated in the project of Chinese Longitudinal Healthy Longevity Survey (CLHLS) conducted in 2008--2009 were selected from 7 Longevity Areas. 2029 people aged 40 and over attended the study from March to June , 2009 , including 469 aged 40 and over,436 aged 60 and over,346 aged 80 and over,380 aged 90 and over, 398 centenarians. Information, including socio-demographic, were collected by self-designed questionnaire. Calibrated instruments were used by the clinical personnel who had worked over 3 years to manually check subjects' health. Venous blood and urine samples were collected for blood and urine routine test, plasma macro and trace elements test, plasma biological test, using standard methods such as instrument analysis, atomic absorption spectrometry. Data analysis was conducted using descriptive statistical methods. Results In the groups aged 40 and over,60 and over,80 and over,90 and over, 100 and over, the body mass index (BMI) were (23.2 ± 4. 6), (22. 1 ± 3.7), (20. 2 ± 3.4), (20. 2 ± 3.9) and (19. 1±5.0)kg/m~2 in males(F=22.78,P<0.01) and (23.3±4.0),(21.6±3.5),(19.7±3.9), (19.0 ± 4. 8), (18. 4 ± 3. 8) kg/m~2 in females (F = 51.84, P < 0. 01) ; the prevalence of hypertension were 38. 3% (80/209) ,60. 8% (166/273) ,63.5% (106/167) ,61.8% (68/110) ,54. 8% (34/62) in males (χ~2 = 34.26, P< 0.01) and 32.3% (84/260), 60. 1% (98/163), 69.8% (125/179), 61.5% (166/270), 58.9% (198/336) in females (χ~2 = 78.45, P < 0. 01) ; the prevalence of diabetes were 10.5% (22/209),12.5% (34/273),9.0% (15/167),18.2% (20/110),12.9% (8/62) in males (χ~2=5.92,P=0.20) and4.2% (11/260),!5.3% (25/163),10.1% (18/179),12.2% (33/270), 7.4% (25/336) in females(χ~2 = 19. 25, P < 0. 01). In groups aged 40 and over,90 and over, 100 and over, the superoxide dismutase (SOD) activity were (29. 03 ± 5.79), (30. 93 ± 5.39), (31.63 ± 5.92) U/ml in males(F =4. 40,P <0. 05) and (28. 27 ±6. 25), (30. 86±5. 72), (31.55 ±5. 25) U/ml in females(F= 13. 13 ,P <0. 05) ; levels of plasma calcium were (3.63 ± 1.08), (3.09 ±0. 91), (3. 34 ± 1.07) mmol/L in males (F = 5.71 ,P <0. 01) and (3. 84± 1.02), (3. 19± 1.16), (3. 38±1.16) mmol/L in females (F = 11.61 ,P <0. 01) ; levels of selenium were (1.44 ±0. 86), (1.28±0. 60), (1.75±0. 57) μmol/L in males (F=3.79,P<0. 05) and (1.44±0. 80),(1.48 ±0. 81),(1.78 ±0.80) μmol/L in females (F= 8. 69, P < 0. 01) ; levels of iron were (63.25 ± 49. 05), (71.86± 54. 16), (138. 36 ± 77.60) μmol/L in males (F = 22. 78, P < 0. 01) and (64. 86 ± 57. 72), (74. 56 ± 56. 93), (106. 56 ± 74. 08) μmol/L in females (F = 17. 88, P < 0. 01) ; levels of copper were (23.49 ± 12. 85), (17.96 ± 7.57), (22. 33 ± 6. 89) μmol/L in males (F = 5.18, P < 0. 01) and (21.52 ± 10. 63), (19.60 ± 9. 57), (22. 99 ± 8.71) μmol/L in females (F = 5. 68, P < 0. 01) ; positive rates of high-sensitivity c-reactive protein (hsCRP) were 5.5% (8/146),24.0% (18/75),31.3% (10/32) in males (χ~2= 22.62,P<0.01) and 9.8% (12/122), 19.6% (40/204),25.1% (49/195) in females (χ~2 = 11.24, P<0.01).Conclusion The results indicate that the centenarians have lower chronic diseases risks and higher anti-oxidants activity compared with other age groups, and have a high level of nutritional elements compared with those aged 90 and over. However,it is more common for them suffering from inflammation.
