CAJ | 학술논문

乳酸-乙醇酸共聚物(PLGA)复合纤维具有良好的生物相容性和生物可降解性,且降解速率可由相对分子质量和共聚物组成来调控.采用同轴静电纺丝法制备以PLGA为壳层材料、聚乙烯基吡咯烷酮(PVP)为内芯材料的复合纤维,研究两种模型药物(5-氟尿嘧啶和硝苯地平)在同轴复合纤维载体中的药物释放行为,并用扫描、透射电镜观察复合纤维的形貌与结构,用紫外分光光度计测量载药量和累积释放率.实验结果表明,通过改变芯、壳纺丝液浓度、PLGA相对分子质量以及共聚物中LA和GA的组成比,可制得具有芯-壳结构且直径大小不同的复合纤维.采用相同电纺丝条件,可以将不同药物以相同载药量包覆于复合纤维中,但药物的释放行为不相同.
유산-을순산공취물(PLGA)복합섬유구유량호적생물상용성화생물가강해성,차강해속솔가유상대분자질량화공취물조성래조공.채용동축정전방사법제비이PLGA위각층재료、취을희기필각완동(PVP)위내심재료적복합섬유,연구량충모형약물(5-불뇨밀정화초분지평)재동축복합섬유재체중적약물석방행위,병용소묘、투사전경관찰복합섬유적형모여결구,용자외분광광도계측량재약량화루적석방솔.실험결과표명,통과개변심、각방사액농도、PLGA상대분자질량이급공취물중LA화GA적조성비,가제득구유심-각결구차직경대소불동적복합섬유.채용상동전방사조건,가이장불동약물이상동재약량포복우복합섬유중,단약물적석방행위불상동.
Poly (lactic-co-glycolic acid) (PLGA ) is biocompatible and biodegradable, and the degradation rate can be adjusted by changing molecular weights and composition of PLGA.In this work, fibers with core-shell structure were prepared through coaxial electrospinning technique.Two model drugs (5-fluorouracil and nifedipine) were encapsulated in the eletrospun fibers respectively.The shell was composed of poly (lactic-co-glycolic acid) (PLGA), and the core was made of poly (vinyl pyrrolidone) (PVP).Release behaviors of the two drugs were investigated.Morphology and core-shell structure of the fibers were characterized by scanning and transmission electron microscope.The cumulative release was examined by ultraviolet spectrophotometry.Experimental results indicated that the composite fibers with core-shell structure and different diameters could be fabricated by adjusting LA and GA content in PLGA, molecular weights of PLGA, concentrations of the raw solutions for core and shell.Different drugs loaded in the same composite fibers exhibited different release profiles.Loading 5-fluorouracil released in a burst manner, while nifedipine displayed a slow releasing.