中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2010年
8期
893-894
,共2页
肝肿瘤%CD44v6%流式细胞术
肝腫瘤%CD44v6%流式細胞術
간종류%CD44v6%류식세포술
Liver neoplasms%CD44v6%Flow cytometry
目的 探讨CD44v6在肝癌组织中的表达及其与肝癌患者预后的关系.方法 应用流式细胞术定量检测新鲜肝癌组织中CD44v6的表达量,并与正常肝组织进行比较.分析CD44v6表达与肝癌患者预后的关系.结果 肝癌组织CD44v6蛋白表达率为91.9%(34/37),显著高于正常肝组织的18.8%(3/16),差异有统计学意义(P＜0.05).肿瘤的浸润程度、分化程度不同,CD44v6蛋白表达量间差异有统计学意义(P＜0.05);发生淋巴结转移的肝癌患者,CD44v6蛋白表达量(10.56±0.21)与无淋巴结转移患者的表达量(4.34±0.19)比较,差异有统计学意义(P＜0.05).结论 CD44v6是评价肝癌预后的一个可靠指标,CD44v6高表达提示肝癌患者预后不良.
目的 探討CD44v6在肝癌組織中的錶達及其與肝癌患者預後的關繫.方法 應用流式細胞術定量檢測新鮮肝癌組織中CD44v6的錶達量,併與正常肝組織進行比較.分析CD44v6錶達與肝癌患者預後的關繫.結果 肝癌組織CD44v6蛋白錶達率為91.9%(34/37),顯著高于正常肝組織的18.8%(3/16),差異有統計學意義(P＜0.05).腫瘤的浸潤程度、分化程度不同,CD44v6蛋白錶達量間差異有統計學意義(P＜0.05);髮生淋巴結轉移的肝癌患者,CD44v6蛋白錶達量(10.56±0.21)與無淋巴結轉移患者的錶達量(4.34±0.19)比較,差異有統計學意義(P＜0.05).結論 CD44v6是評價肝癌預後的一箇可靠指標,CD44v6高錶達提示肝癌患者預後不良.
목적 탐토CD44v6재간암조직중적표체급기여간암환자예후적관계.방법 응용류식세포술정량검측신선간암조직중CD44v6적표체량,병여정상간조직진행비교.분석CD44v6표체여간암환자예후적관계.결과 간암조직CD44v6단백표체솔위91.9%(34/37),현저고우정상간조직적18.8%(3/16),차이유통계학의의(P＜0.05).종류적침윤정도、분화정도불동,CD44v6단백표체량간차이유통계학의의(P＜0.05);발생림파결전이적간암환자,CD44v6단백표체량(10.56±0.21)여무림파결전이환자적표체량(4.34±0.19)비교,차이유통계학의의(P＜0.05).결론 CD44v6시평개간암예후적일개가고지표,CD44v6고표체제시간암환자예후불량.
Objective To study the expressions of CD44v6 proteins in hepatoma and its relationship with the patients' prognosis.Methods The expressions of CD44v6 protein were detected by flow cytometry,the expression of CD44v6 and significant hepatoma prognostic factor was analyzed by multivariate Cox proportional hazards regression model.Results Most of hepatoma (34/37,91.9%) were expressed high level of CD44v6 protein,its level was higher than normal liver tissues(3/16,18.7%),and its expression was tightly associated with tumor invasion,lymph node metastasis and Dukes stage by analysis of multivariate Cox proportional hazard model.Conclusion CD44v6 expression was evaluated a reliable indicator of poor prognosis for hepatoma,it was a target for hepatoma therapy.
