CAJ | 학술논문

目的研究鬼箭羽不同提取部位对糖尿病大鼠的药理作用,追踪有效部位,为进一步明确鬼箭羽治疗糖尿病的有效成分和建立其质量控制标准打下基础.方法腹腔注射链脲菌素(STZ)复制大鼠糖尿病模型,并分为模型组、治疗组,健康大鼠为正常组.治疗组分别给予鬼箭羽不同提取部位即石油醚、乙酸乙酯、正丁醇、水、残渣、精制多糖部位.4周后观察体重增加量及血糖、血脂、肌酐、尿素和全血黏度、全血高/低切还原黏度等.结果石油醚、水和乙酸乙酯部位降糖作用明显;正丁醇和精制多糖部位降血肌酐作用明显,其余各组降血尿素作用显著;残渣部位能明显降低低密度脂蛋白、胆固醇含量;水部位降低血液黏度作用明显,精制多糖部位能显著提高红细胞压积;除精制多糖组体重减轻外其余治疗组体重均增加.结论鬼箭羽各提取部位在降糖、降脂、改善肾功能、降低血液黏度、增加体重方面作用各有侧重,单味鬼箭羽可通过影响糖尿病发病的不同环节治疗和预防糖尿病及其并发症.
목적 연구귀전우불동제취부위대당뇨병대서적약리작용,추종유효부위,위진일보명학귀전우치료당뇨병적유효성분화건립기질량공제표준타하기출.방법 복강주사련뇨균소(STZ)복제대서당뇨병모형,병분위모형조、치료조,건강대서위정상조.치료조분별급여귀전우불동제취부위즉석유미、을산을지、정정순、수、잔사、정제다당부위.4주후관찰체중증가량급혈당、혈지、기항、뇨소화전혈점도、전혈고/저절환원점도등.결과 석유미、수화을산을지부위강당작용명현;정정순화정제다당부위강혈기항작용명현,기여각조강혈뇨소작용현저;잔사부위능명현강저저밀도지단백、담고순함량;수부위강저혈액점도작용명현,정제다당부위능현저제고홍세포압적;제정제다당조체중감경외기여치료조체중균증가.결론 귀전우각제취부위재강당、강지、개선신공능、강저혈액점도、증가체중방면작용각유측중,단미귀전우가통과영향당뇨병발병적불동배절치료화예방당뇨병급기병발증.
Objective To study the Pharmacological effects of different extract fractions from Guijianyu (Euonymus alatus)on diabetic rats,pursue the effective fractions,make clear the effective constituents of Guijianyu for treating diabetes,and set up the quality control standard.Methods The model of diabetic rat was established by the injection of streptozotocin(sax).All rats were divided into the model group,treatment group and normal group.The treatment group was given the fractions of Guijianyu including petroleum ether,ethyl acetate,n-butyl alcohol,water,residue and rectified polysaccharide respectively.After 4 weeks the body weight,blood sugar(BS),blood fat,creatinine,urea,and whole blood viscosity(WBV)and whole blood reduced viscosity at high or low share rate were observed.Results The fractions of petroleum ether,water and ethyl acetate had significant anti-diabetes effect,n-butyl alcohol and rectified polysaccharide had significant reducing effect on blood creatinine,and other fractions had significant reducing effect on urea.The fraction of residue decreased significantly the content of low-density hpoprotein(LOL)and cholesterol(CH),water decreased WBV,and rectified polysaccharide increased significantly hematocrit(HCT).The body weight was put on by all ffactiom except rectified polysaccharide.Conclusion Different fractions of Guijianyu have different effects in anti-diabetes,anti-hyperlipidemia,improving kidney function,decreasing blood viscosity and putting on body weight.Guijianyu can be used for curing and preventing diabetes and its complications through influencing different links in the development of diabetes.