CAJ | 학술논문

TWIST是胚胎发育过程中的重要转录调控因子,最近发现它在肿瘤转移的起始阶段使癌细胞发生EMT现象,即细胞从上皮极性表型向间质成纤维细胞表型的形态学上的转变,同时伴有上皮细胞分子标记的抑制和间质细胞分子标记的强烈表达,从而促进细胞的运动和迁移,使肿瘤呈现恶性表型,导致患者预后不良.目前已经证实有多种细胞信号通路和细胞内因子参与了TWIST的表达和激活,它们对TWIST功能起重要的调控作用.本文主要就目前TWIST的结构、功能及在肿瘤中的作用作一综述.
TWIST시배태발육과정중적중요전록조공인자,최근발현타재종류전이적기시계단사암세포발생EMT현상,즉세포종상피겁성표형향간질성섬유세포표형적형태학상적전변,동시반유상피세포분자표기적억제화간질세포분자표기적강렬표체,종이촉진세포적운동화천이,사종류정현악성표형,도치환자예후불량.목전이경증실유다충세포신호통로화세포내인자삼여료TWIST적표체화격활,타문대TWIST공능기중요적조공작용.본문주요취목전TWIST적결구、공능급재종류중적작용작일종술.
Objective As a important transcriptional factor during the embryonic development process,recently TWIST has been found to promote the EMT phenomenon in the initiation step of tumor metastasis.EMT is a morphological switch of cells from the epithelial polarized phenotype to the mesenchymal fibroblastoid phenotype,accompanying obvious lost of epithelial marker and strong gain of mesenchymal marker in cells which can result in the tumor manifests malignant phenotype and poor prognosis.At present,many of signal transduction pathways and cellular factors have been reported to involve in the expression and activation of TWIST.In this review,we will comprehensively discuss the progress on the structure,function and the role in tumor of TWIST.