CAJ | 학술논문

目的探讨控制性卵巢刺激(COS)治疗中血清催乳素水平的变化特点.方法收集接收体外受精-胚胎移植的患者72例,共115个周期,采用促性腺激素释放激素激动剂结合促性腺激素(Gn)长、短方案促排卵治疗,定时经阴道B超监测卵泡发育情况及子宫内膜厚度,并采用酶联免疫发光法检测不同时间点血清雌二醇、黄体生成素(LH)、孕酮和催乳素的水平,分析患者雌二醇、LH、孕酮水平与催乳素水平之间的相关性.结果对催乳素与雌二醇水平进行相关和回归分析发现,随着雌二醇水平的上升,催乳素水平有显著上升的趋势,两者呈显著正相关关系(r=0.5897,P＜0.01).对催乳素与孕酮水平进行相关和回归分析发现,孕酮水平随催乳素水平的升高而升高,两者呈显著正相关关系(r=0.1412,P＜0.01).但是LH水平与催乳素水平之间未见明显关联.结论在控制性卵巢刺激治疗中,催乳素的分泌不受Gn的影响,而雌二醇水平的升高可能刺激催乳素的分泌,且催乳素与孕酮水平呈正相关关系.
목적 탐토공제성란소자격(COS)치료중혈청최유소수평적변화특점.방법 수집접수체외수정-배태이식적환자72례,공115개주기,채용촉성선격소석방격소격동제결합촉성선격소(Gn)장、단방안촉배란치료,정시경음도B초감측란포발육정황급자궁내막후도,병채용매련면역발광법검측불동시간점혈청자이순、황체생성소(LH)、잉동화최유소적수평,분석환자자이순、LH、잉동수평여최유소수평지간적상관성.결과 대최유소여자이순수평진행상관화회귀분석발현,수착자이순수평적상승,최유소수평유현저상승적추세,량자정현저정상관관계(r=0.5897,P＜0.01).대최유소여잉동수평진행상관화회귀분석발현,잉동수평수최유소수평적승고이승고,량자정현저정상관관계(r=0.1412,P＜0.01).단시LH수평여최유소수평지간미견명현관련.결론 재공제성란소자격치료중,최유소적분비불수Gn적영향,이자이순수평적승고가능자격최유소적분비,차최유소여잉동수평정정상관관계.
Objective To investigate the variance of peripheral blood prolactin(PRL)in controlled ovarian stimulation.Methods Seventy-two patients,with totally 106 cycles receiving a long protocol of gonadotropin-releasing hormone agonist combined with gonadotropin(Gn)were randomly enrolled in this retrospective study.During controlled ovarian stimulation,peripheral blood hormones were measured by chemiluminescent microparticle immunoassay.Results Prolactin was positively correlated with estradiol (r=0.5897.P＜0.01)while there was no significant correlation between luteinizing hormone and PRLProgesterone had a positive relation with prolactin(r=0.1412,P＜0.01).Conclusions During controlled ovarian stimulation,prolactin secretion is not affected by Gn but may be stimulated by estradiol.Progesterone has a positive relation with prolactin.