CAJ | 학술논문

在抗结核治疗策略中,异烟肼是最重要的一线药物.在过去50年的抗结核治疗中,异烟肼发挥了非常重要的作用,而耐异烟肼结核菌的出现使这种效果减弱.本文从异烟肼的抗结核机制人手,对异烟肼耐药的分子机制作一综述.
재항결핵치료책략중,이연정시최중요적일선약물.재과거50년적항결핵치료중,이연정발휘료비상중요적작용,이내이연정결핵균적출현사저충효과감약.본문종이연정적항결핵궤제인수,대이연정내약적분자궤제작일종술.
Isoniazid is one of the most important first-line drugs of anti-tuberculosis strategy. In the past 50 years, isoniazid played a very important role in anti-tuberculosis treatment. However, with the emergence of isoniazid-resistant Myeobacterium tuberculosis, the efficacy is decreasing. Herein, this article discusses the mechanism of isoniazid action against Mycobacterium tuberculosis, and reviews the molecular mechanism of isoniazid resistance in Myeobacterium tuberculosis.