CAJ | 학술논문

目的观察中国人黄斑区脉络膜厚度(CT)值，并分析其相关影响因素。方法 180名志愿者360只眼纳入本研究。根据不同年龄，将其分为20～29岁组（A组）、30～39岁组（B组）、40～49岁组(C组)、50～59岁组（D组）、60～69岁组（E组）、70～85岁组（F组），分别为33、31、29、30、31、26名。同时，再将志愿者分为＜60岁和≥60岁组，分别为123、57名。采用海德堡频域光相干断层扫描(OCT)的加强厚度成像(EDI)技术，以长度为8.8 mm的扫描线段对后极部黄斑中心凹行0°和90°方位扫描，测量中心凹下CT值；同时测量离中心凹处1、3 mm处上方(S)、下方(I)、颞侧(T)、鼻侧(N)的CT值，分别标记为S1mm、I1 mm、T1mm、N1mm、S3mm、I3mm、T3 mm、N3mm。观察不同方位、性别、眼别及年龄组受检者间CT的变化情况。对比分析＜60岁和≥60岁组CT与年龄、屈光度的相关性。结果受检者中心凹下平均CT值为(262.78±84.38) μm。S1mm、I1 mm、T1 mm、N1mm、S3mm、I3mm、T3mm、N3 mm平均CT值分别与中心凹下CT值比较，除S1mm、T1mm方位间差异无统计学意义外(P＞0.05)，其余方位间差异均有统计学意义(P＜0.05)。不同性别、眼别间平均CT值差异均无统计学意义(P＞0.05)。不同年龄组间中心凹下平均CT值比较，A、B、C、D4组间差异无统计学意义(P＞0.05)；E、F组较A、B、C、D组明显降低，差异有统计学意义(P＜0.05)。相关性分析发现，＜60岁组年龄与CT无相关性(r=-0.055，P＞0.05)，屈光度与CT之间呈正相关(r=0.147，P＜0.05)；≥60岁组年龄与CT呈高度线性负相关(r=-0.543，P＜0.05),屈光度与CT之间无相关性（r=-0.008，P＞0.05）。结论中国人黄斑区CT值为（262.78±84.38）μm。屈光度是＜60岁者CT的主要影响因素，年龄是≥60岁者CT的主要影响因素。
목적 관찰중국인황반구맥락막후도(CT)치，병분석기상관영향인소。방법 180명지원자360지안납입본연구。근거불동년령，장기분위20～29세조（A조）、30～39세조（B조）、40～49세조(C조)、50～59세조（D조）、60～69세조（E조）、70～85세조（F조），분별위33、31、29、30、31、26명。동시，재장지원자분위＜60세화≥60세조，분별위123、57명。채용해덕보빈역광상간단층소묘(OCT)적가강후도성상(EDI)기술，이장도위8.8 mm적소묘선단대후겁부황반중심요행0°화90°방위소묘，측량중심요하CT치；동시측량리중심요처1、3 mm처상방(S)、하방(I)、섭측(T)、비측(N)적CT치，분별표기위S1mm、I1 mm、T1mm、N1mm、S3mm、I3mm、T3 mm、N3mm。관찰불동방위、성별、안별급년령조수검자간CT적변화정황。대비분석＜60세화≥60세조CT여년령、굴광도적상관성。결과 수검자중심요하평균CT치위(262.78±84.38) μm。S1mm、I1 mm、T1 mm、N1mm、S3mm、I3mm、T3mm、N3 mm평균CT치분별여중심요하CT치비교，제S1mm、T1mm방위간차이무통계학의의외(P＞0.05)，기여방위간차이균유통계학의의(P＜0.05)。불동성별、안별간평균CT치차이균무통계학의의(P＞0.05)。불동년령조간중심요하평균CT치비교，A、B、C、D4조간차이무통계학의의(P＞0.05)；E、F조교A、B、C、D조명현강저，차이유통계학의의(P＜0.05)。상관성분석발현，＜60세조년령여CT무상관성(r=-0.055，P＞0.05)，굴광도여CT지간정정상관(r=0.147，P＜0.05)；≥60세조년령여CT정고도선성부상관(r=-0.543，P＜0.05),굴광도여CT지간무상관성（r=-0.008，P＞0.05）。결론 중국인황반구CT치위（262.78±84.38）μm。굴광도시＜60세자CT적주요영향인소，년령시≥60세자CT적주요영향인소。
Objective To observe the choroidal thickness and its relationship with age and refraction status in Chinese population. Methods180 healthy volunteers (360 eyes) were enrolled in this study.Based on the age, the volunteers were divided into A (20-29 years old), B (30-39 year old), C (40-49 years old), D (50-59 year old), E (60-69 year old), and F (70-85 year old) group, with 33, 31, 29, 30, 31, 26volunteers respectively. And the volunteers were divided into ＜60 years old group with 123 volunteers and ≥ 60 years old group with 57 volunteers. Enhanced depth imaging (EDI) choroidal scans were obtained in all eyes by using spectral-domain optical coherence tomography. Subfoveal choroidal thickness (CT) and CT at 1 mm/3 mm temporal, nasal, superior, inferior to the fovea (S1 mm, I1 mm, T1 mm, N1 mm, S3 mm, I3 mm,T3mm, N3 mm) were measured. The differences of CT between different quadrants, genders, eyes and ages were comparatively analyzed. The correlations between age, refraction status and CT in the volunteers of ＜60 years old and ≥ 60 years old group were analyzed. Results The subfoveal CT was (262.78 ± 84.38)μm. The differences were significant between subfoveal CT and all the quadrants CT (P＜0. 05) except for S1 mm and T1mm(P＞0. 05). There was no difference between genders or eyes in subfoveal CT (P＞0. 05).There was no difference between A, B, C, D group in subfoveal CT (P＞0.05). The subfoveal CT of E and F group were thinner than A, B, C, D group (P＜0.05). In the ＜60 years old group, there was a positive correlation between refraction status and CT (r=0. 147, P＜0.05) ; but no correlation between age and CT (r=-0. 055, P＞0. 05). In the ≥ 60 years old group, there was a significant negative correlation between CT and age (r=-0. 543, P＜0. 05), but no correlation between refraction status and CT (r =-0. 008,P＞0.05). Conclusions The average subfoveal CT in Chinese population was (262.78±84.38) μm. The refraction status is the main influence factors in subjects ＜60 years old, while the age is the main influence factors in subjects ≥60 years old.