中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2011年
6期
490-493
,共4页
张琳%田英%杨先丰%崔昌%高宇%王筱金%王沛%丁问微%施蓉%王英%金军%金萍
張琳%田英%楊先豐%崔昌%高宇%王篠金%王沛%丁問微%施蓉%王英%金軍%金萍
장림%전영%양선봉%최창%고우%왕소금%왕패%정문미%시용%왕영%금군%금평
多溴联苯类%婴儿,新生%胎血%胚胎发育
多溴聯苯類%嬰兒,新生%胎血%胚胎髮育
다추련분류%영인,신생%태혈%배태발육
Polybrominated biphenyls%Infant,newborn%Fetal blood%Embryonic development
目的 调查上海市某医院新生儿脐带血中多溴联苯醚(polybrominated diphenyl ethers,PBDEs)浓度水平,并分析胎儿期PBDEs暴露对新生儿出生结局的影响.方法 于2006年9月至2007年4月,对上海市某医院50名入院分娩的孕妇进行问卷调查,孕妇均为单胎妊娠,排除高血压、糖尿病、HIV感染和不良药物史.收集新生儿脐带血样本,使用气相色谱-负化学电离源-质谱法检测脐带血中7种PBDEs[溴代联苯醚(BDE)-28、BDE-47、BDE-99、BDE-100、BDE-153、BDE-154、BDE-183]浓度,计算PBDEs总浓度(∑,PBDEs),并进一步分析脐带血中PBDEs浓度水平对新生儿出生结局的影响.结果 上海市某医院新生儿身长为(50.15±0.75)cm,体重为(3.49±0.42)kg,胸围为(34.76±1.51)cm,头围为(35.03±1.40)cm,体质指数为(13.76±1.36)kg/m2.新生儿脐带血中∑,PBDEs中位数浓度(范围)为14.06(1.03～379.73)ng/g脂重(lipid weight,1w).BDE-28、BDE-47、BDE-99、BDE-100、BDE-153、BDE-154、BDE-183检出率分别为22%(11/50)、22%(11/50)、98%(49/50)、72%(36/50)、76%(38/50)、90%(45/50)、14%(7/50).各同族体中位数浓度(范围)分别为:BDE-28为<检测限(LOD)(＜LOD～137.20 ng/g 1w),BDE-47为＜LOD(＜LOD-33.17 ng/g 1w),BDE-99为7.54(＜LOD-94.01)ng/g 1w,BDE-100为1.57(＜LOD-46.95)ng/g 1w,BDE-153为0.63(＜LOD-79.08)ng/g 1w,BDE-154为0.63(＜LOD-22.30)ng/g 1w,BDE-183为＜LOD(＜LOD-21.63 ng/g 1w).新生儿体质指数与BDE-99(r=-0.347,P＜0.05)和BDE-154(r=-0.292,P＜0.05)浓度呈负相关.将出生结局按照累计频率25%分为低(≤25%)、高(＞25%)两组,BDE-99在低身长组(≤50 cm)和高身长组(＜50 cm)的几何均数分别为10.59 ng/g 1w和3.60 ng/g 1w,二者差异有统计学意义(t=2.32,P=0.03).结论 上海市某医院新生儿脐带血中普遍存在PBDEs,胎儿期PBDEs暴露可影响新生儿出生结局.
目的 調查上海市某醫院新生兒臍帶血中多溴聯苯醚(polybrominated diphenyl ethers,PBDEs)濃度水平,併分析胎兒期PBDEs暴露對新生兒齣生結跼的影響.方法 于2006年9月至2007年4月,對上海市某醫院50名入院分娩的孕婦進行問捲調查,孕婦均為單胎妊娠,排除高血壓、糖尿病、HIV感染和不良藥物史.收集新生兒臍帶血樣本,使用氣相色譜-負化學電離源-質譜法檢測臍帶血中7種PBDEs[溴代聯苯醚(BDE)-28、BDE-47、BDE-99、BDE-100、BDE-153、BDE-154、BDE-183]濃度,計算PBDEs總濃度(∑,PBDEs),併進一步分析臍帶血中PBDEs濃度水平對新生兒齣生結跼的影響.結果 上海市某醫院新生兒身長為(50.15±0.75)cm,體重為(3.49±0.42)kg,胸圍為(34.76±1.51)cm,頭圍為(35.03±1.40)cm,體質指數為(13.76±1.36)kg/m2.新生兒臍帶血中∑,PBDEs中位數濃度(範圍)為14.06(1.03～379.73)ng/g脂重(lipid weight,1w).BDE-28、BDE-47、BDE-99、BDE-100、BDE-153、BDE-154、BDE-183檢齣率分彆為22%(11/50)、22%(11/50)、98%(49/50)、72%(36/50)、76%(38/50)、90%(45/50)、14%(7/50).各同族體中位數濃度(範圍)分彆為:BDE-28為<檢測限(LOD)(＜LOD～137.20 ng/g 1w),BDE-47為＜LOD(＜LOD-33.17 ng/g 1w),BDE-99為7.54(＜LOD-94.01)ng/g 1w,BDE-100為1.57(＜LOD-46.95)ng/g 1w,BDE-153為0.63(＜LOD-79.08)ng/g 1w,BDE-154為0.63(＜LOD-22.30)ng/g 1w,BDE-183為＜LOD(＜LOD-21.63 ng/g 1w).新生兒體質指數與BDE-99(r=-0.347,P＜0.05)和BDE-154(r=-0.292,P＜0.05)濃度呈負相關.將齣生結跼按照纍計頻率25%分為低(≤25%)、高(＞25%)兩組,BDE-99在低身長組(≤50 cm)和高身長組(＜50 cm)的幾何均數分彆為10.59 ng/g 1w和3.60 ng/g 1w,二者差異有統計學意義(t=2.32,P=0.03).結論 上海市某醫院新生兒臍帶血中普遍存在PBDEs,胎兒期PBDEs暴露可影響新生兒齣生結跼.
목적 조사상해시모의원신생인제대혈중다추련분미(polybrominated diphenyl ethers,PBDEs)농도수평,병분석태인기PBDEs폭로대신생인출생결국적영향.방법 우2006년9월지2007년4월,대상해시모의원50명입원분면적잉부진행문권조사,잉부균위단태임신,배제고혈압、당뇨병、HIV감염화불량약물사.수집신생인제대혈양본,사용기상색보-부화학전리원-질보법검측제대혈중7충PBDEs[추대련분미(BDE)-28、BDE-47、BDE-99、BDE-100、BDE-153、BDE-154、BDE-183]농도,계산PBDEs총농도(∑,PBDEs),병진일보분석제대혈중PBDEs농도수평대신생인출생결국적영향.결과 상해시모의원신생인신장위(50.15±0.75)cm,체중위(3.49±0.42)kg,흉위위(34.76±1.51)cm,두위위(35.03±1.40)cm,체질지수위(13.76±1.36)kg/m2.신생인제대혈중∑,PBDEs중위수농도(범위)위14.06(1.03～379.73)ng/g지중(lipid weight,1w).BDE-28、BDE-47、BDE-99、BDE-100、BDE-153、BDE-154、BDE-183검출솔분별위22%(11/50)、22%(11/50)、98%(49/50)、72%(36/50)、76%(38/50)、90%(45/50)、14%(7/50).각동족체중위수농도(범위)분별위:BDE-28위<검측한(LOD)(＜LOD～137.20 ng/g 1w),BDE-47위＜LOD(＜LOD-33.17 ng/g 1w),BDE-99위7.54(＜LOD-94.01)ng/g 1w,BDE-100위1.57(＜LOD-46.95)ng/g 1w,BDE-153위0.63(＜LOD-79.08)ng/g 1w,BDE-154위0.63(＜LOD-22.30)ng/g 1w,BDE-183위＜LOD(＜LOD-21.63 ng/g 1w).신생인체질지수여BDE-99(r=-0.347,P＜0.05)화BDE-154(r=-0.292,P＜0.05)농도정부상관.장출생결국안조루계빈솔25%분위저(≤25%)、고(＞25%)량조,BDE-99재저신장조(≤50 cm)화고신장조(＜50 cm)적궤하균수분별위10.59 ng/g 1w화3.60 ng/g 1w,이자차이유통계학의의(t=2.32,P=0.03).결론 상해시모의원신생인제대혈중보편존재PBDEs,태인기PBDEs폭로가영향신생인출생결국.
Objective To explore the concentration of polybrominated diphenyl ethers(PBDEs)in umbilical cord serum and analyze the influence of exposure to PBDEs during fetal stage on newborn birth outcomes in Shanghai.Methods Fifty delivery women in a Shanghai hospital were surveyed by questionnaire.and the umbilical cord serum were collected from September 2006 to April 2007.All the delivery women were singleton pregnancies,excluding hish blood pressure,diabetes,HIV infection and adverse medical history.Seven congeners(BDE-28,BDE-47,BDE-99,BDE-100,BDE-153,BDE-154 and BDE-183) were measured by gas chromatography-negative chemical ionization-mass spectrometry and the influencing factors were anatyzed. Results Newborns'length.weight,chest circumference,head circumference and body mass index(BMI)were(50.15±0.75)cm,(3.49±0.42)kg,(34.76±1.51)cm,(35.03 ±1.40)cm,(13.76±1.36)kg/m2,respectively.The median of ∑7 PBDEs concentration in umbilical cord serum was 14.06(1.03-379.73)ng/g lipid weight(1w).The detection rate of BDE-28,BDE-47,BDE-99,BDE-100,BDE-153,BDE-154 and BDE-183 were 22%(11/50),22%(11/50),98%(49/50).72%(36/50),76%(38/50),90%(45/50)and 14%(7/50),respectively.The median(range)of PBDEs (BDE-28,BDE-47,BDE-99,BDE-100,BDE-153,BDE-154,BDE-183)congeners were ＜LOD (＜LOD-137.20 ng/g 1w),＜LOD(＜LOD-33.17 ng/g 1w),7.54.ng/g 1w(＜LOD-94.01 ng/g 1w),1.57 ng/g 1w(＜LOD-46.95 ng/g 1w),0.63.ng/g 1w(＜LOD-79.08 ng/g 1w),0.63 ng/g 1w(＜LOD-22.30 ng/g 1w)and＜LOD(＜LOD-21.63 ng/g 1w),respectiveIy.The newborns'BMI showed a negative correlation with BDE-99(r=-0.347.P＜0.05)and BDE.154(r=-0.292.P＜0.05).BDE-99in low-length group(≤50 cm,10.59 ng/g 1w) was significantly higher(t=2.32,P=0.03)than that in high-length group(＞50 cm,3.60 ng/g 1w).Conclusion PBDEs were commonly detected in newborns'umbilical cord serum in this study.Our findings indicated that exposure to PBDEs adversely affected the development of the newborns.
