CAJ | 학술논문

目的探讨骨和软组织肿瘤磁共振磷谱(31P-MRS)的变化特点.方法对41例经病理证实的骨和软组织肿瘤患者的18个良性肿瘤病灶、28个恶性肿瘤病灶及其相邻部位正常肌肉组织,应用3.0T MR机进行31P-MRS分析,测量波谱中磷酸单酯(PME)、无机磷(Pi)、磷酸二酯(PDE)、磷酸肌酸(Pcr)、三磷酸腺苷γ-峰(γ-ATP)、α-峰(α-ATP)和β-峰(β-ATP)的峰下面积.分别以β-ATP、三磷酸核苷(NTP)和Pcr为参照,计算各代谢产物的相对比值.根据Pi相对于Pcr化学位移的变化计算细胞内pH值.结果良、恶性肿瘤组中Pcr/PME、PME/NTP与正常对照组比较,差异均有统计学意义(P<0.05).良、恶性肿瘤组中PME/β-ATP与PME/NTP比较,差异有统计学意义(P<0.05).结论 Pcr/PME和PME/NTP是诊断骨和软组织肿瘤的潜在指标,PME/β-ATP和PME/NTP是鉴别骨和软组织肿瘤良、恶性的潜在指标.
목적 탐토골화연조직종류자공진린보(31P-MRS)적변화특점.방법 대41례경병리증실적골화연조직종류환자적18개량성종류병조、28개악성종류병조급기상린부위정상기육조직,응용3.0T MR궤진행31P-MRS분석,측량파보중린산단지(PME)、무궤린(Pi)、린산이지(PDE)、린산기산(Pcr)、삼린산선감γ-봉(γ-ATP)、α-봉(α-ATP)화β-봉(β-ATP)적봉하면적.분별이β-ATP、삼린산핵감(NTP)화Pcr위삼조,계산각대사산물적상대비치.근거Pi상대우Pcr화학위이적변화계산세포내pH치.결과 량、악성종류조중Pcr/PME、PME/NTP여정상대조조비교,차이균유통계학의의(P<0.05).량、악성종류조중PME/β-ATP여PME/NTP비교,차이유통계학의의(P<0.05).결론 Pcr/PME화PME/NTP시진단골화연조직종류적잠재지표,PME/β-ATP화PME/NTP시감별골화연조직종류량、악성적잠재지표.
Objective To study the characteristic changes of 31P-MR spectroscopy of bone and soft tissue tumors. Methods 41 patients were examined by phosphorus surface coil of 3 tesla MR machine, including 18 benign tumor foci and 28 malignant foci, and adjacent normal muscles. The areas under the peaks of various metabolites in the spectra were measured, including phosphomonoester(PME), inorganic phosphours (Pi), phosphodiester(PDE), phosphocreatine ( Pcr ), adenosine triphosphate (ATP) γ, α, β. The ratios of the metabolites to β-ATP, NTP and Pcr were calculated. Intracellular pH was calculated according to the chemical shift change of Pi relative to Per. Results The ratios of Pcr/PME and PME/NTP in benign and malignant tumor groups were significantly different from those of the normal group ( P < 0.05). Between benign and malignant tumor groups, the ratios of PME/β-ATP and PME/NTP were significantly different (P < 0.05). Conclusion Pcr/PME and PME/NTP are potential diagnostic indexes of bone and soft tissue tumors. PME/β-ATP and PME/NTP are potential indexes of differential diagnosis of bone and soft tissue tumors.