CAJ | 학술논문

目的：系统评价文拉法辛缓释剂与帕罗西汀治疗抑郁症的疗效及不良反应。方法计算机检索Cochrane Library、Pubmed、Sicense Direct、EMbase、CBM、VIP、CNKI、万方数据库，纳入文拉法辛缓释剂与帕罗西汀比较治疗抑郁症随机对照试验（RCT），按照 Cochrane Handbook 5．0的质量评价标准评价纳入研究的质量后，采用 RevMan 5．0软件进行Meta 分析。结果共纳入9个RCT，合计633例抑郁症患者。Meta分析结果显示：①治疗8周后文拉法辛缓释剂组与帕罗西汀组的有效率差异无统计学意义[OR＝1．10，95％CI（0．67，1．82），P＝0．70]，其最终治愈率差异亦无统计学意义[OR＝1．29，95％CI（0．91，1．82），P＝0．16]。但是治疗2周后文拉法辛缓释剂组汉密尔顿抑郁量表评分改善优于帕罗西汀组[MD ＝-1．30，95％CI（-1．50，-1．10），P＝0．00001]，提示文拉法辛缓释剂起效较帕罗西汀快。②不良反应：两组的不良反应相似，便秘、口干、恶心等常见不良反应的发生率无明显的统计学差异。结论2种药物远期疗效相当，但文拉法辛缓释剂起效较快；两组不良反应相似，症状均较轻，安全性较好。
목적：계통평개문랍법신완석제여파라서정치료억욱증적료효급불량반응。방법계산궤검색Cochrane Library、Pubmed、Sicense Direct、EMbase、CBM、VIP、CNKI、만방수거고，납입문랍법신완석제여파라서정비교치료억욱증수궤대조시험（RCT），안조 Cochrane Handbook 5．0적질량평개표준평개납입연구적질량후，채용 RevMan 5．0연건진행Meta 분석。결과공납입9개RCT，합계633례억욱증환자。Meta분석결과현시：①치료8주후문랍법신완석제조여파라서정조적유효솔차이무통계학의의[OR＝1．10，95％CI（0．67，1．82），P＝0．70]，기최종치유솔차이역무통계학의의[OR＝1．29，95％CI（0．91，1．82），P＝0．16]。단시치료2주후문랍법신완석제조한밀이돈억욱량표평분개선우우파라서정조[MD ＝-1．30，95％CI（-1．50，-1．10），P＝0．00001]，제시문랍법신완석제기효교파라서정쾌。②불량반응：량조적불량반응상사，편비、구간、악심등상견불량반응적발생솔무명현적통계학차이。결론2충약물원기료효상당，단문랍법신완석제기효교쾌；량조불량반응상사，증상균교경，안전성교호。
Objective To systematically evaluate the efficacy and safety of venlafaxine extended release versus paroxetine for treating depression.Methods According to the computer retrieval from Cochrane Library,Pub med,Science Direct,Embase,CBM,VIP,CNKI,Wan-fang database,we collected the randomized controlled trails (RCTs)on venlafaxine extended release versus paroxtine for treating depression. The quality of the included trails was assessed according to the Cochrane Handbook 5.0,and the systematic analysis was conducted by using Revman 5.0 software.Results a)After eight-week treatment,there were no significant differences in the effective rate (OR=1.10,95%CI 0.67 to 1.82,P=0.70)and the final cure rate (OR=1.29,95% CI 0.91 to 1.82,P=0.16)between venlafaxine extended release and paroxetine groups.However,compared with paroxetine group,venlafaxine extended release group presented advantages (MD=-1.30,95%CI-1.50 to -1.10,P=0.00001)in the improvement of Hamilton Depression Rating Scale score after 2-week treatment,suggesting a rapid onset of venlafaxine extended release.b)Adverse effects were similar between two groups.Constipation,dry mouth,nausea,dizziness,sweating and other common adverse events were not significantly different between the two groups.Conclusion Two drugs are the same in long-term efficacy,but the onset time of venlafaxine extended release is earlier.The adverse reactions of the two groups are similar.The two drugs both present mild symptoms and good safety.