CAJ | 학술논문

聚乳酸(PLA)作为药物载体材料存在因疏水性强而导致的药物释放速率难控以及在循环系统中停留时间短等问题.研究表明,在PLA中引入乙醇酸(GA)可提高材料降解速率,引入聚乙二醇(PEG)则可延长共聚物在循环系统中的停留时间.研究以丙交酯(LA)和对二氧环己酮(PDO)为主要原料,在辛酸亚锡-乙二醇共引发体系的存在下,通过熔融开环聚合制备出了端羟基聚(丙交酯-co-对二氧环己酮)(HO-P(LA-co-PDO)-OH).这种同时具有PLA、GA和EG结构单元的大分子二醇可望成为一种降解速率可控、在循环系统中停留时间可调的新型药物载体材料.采用DSC、~1H NMR、~(13)C NMR和GPC-MALLs等对其结构和热学性能进行了表征.分子量检测结果表明,HO-P(LA-co-PDO)-OH的分子量随原料中PDO/LA摩尔比的减小而增大.
취유산(PLA)작위약물재체재료존재인소수성강이도치적약물석방속솔난공이급재순배계통중정류시간단등문제.연구표명,재PLA중인입을순산(GA)가제고재료강해속솔,인입취을이순(PEG)칙가연장공취물재순배계통중적정류시간.연구이병교지(LA)화대이양배기동(PDO)위주요원료,재신산아석-을이순공인발체계적존재하,통과용융개배취합제비출료단간기취(병교지-co-대이양배기동)(HO-P(LA-co-PDO)-OH).저충동시구유PLA、GA화EG결구단원적대분자이순가망성위일충강해속솔가공、재순배계통중정류시간가조적신형약물재체재료.채용DSC、~1H NMR、~(13)C NMR화GPC-MALLs등대기결구화열학성능진행료표정.분자량검측결과표명,HO-P(LA-co-PDO)-OH적분자량수원료중PDO/LA마이비적감소이증대.
The incorporation of glycolic acid (GA) into polylactic acid (PLA) resulted in fastened and controllable degradation rate of the obtained copolymer, and the copolymerization of poly(ethylene glycol) (PEG) with PLA produced block copolymers exhibiting extended residence time in circulation systems. In this study, pdioxanone (PDO) was employed to copolymerize with DL-lactide (LA) via ring-opening melt polymerization using Sn(Oct)_2 as an initiator and ethylene glycol as a co-initiator. The obtained hydroxyl-terminated polydactide-co-p-dioxanone) copolymers (HOP(LA-co-PDO)-OH) were such a copolymer consisting of PLA, GA and EG, hopefully becoming a novel drug carrier material integrating controllable degradation rate together with extended residence time. ~1H NMR, ~(13)C NMR, DSC and GPC-MALLS were employed to characterize the copolymers, and the effect of PDO/LA molar ratios in the feedstock was investigated on the molecular weights of HOP(LA-co-PDO)-OH. The results confirmed the successful synthesis of HOP(LA-co-PDO)-OH and revealed that the molecular weights of HOP(LA-co-PDO)-OH increased with decreasing PDO/LA ratios.